eF-site ID 2v2h-C PDB Code 2v2h Chain C click to enlarge Title The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL Source (TPIS_TRYBB) Sequence C:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV WAIGTGKVLTPQQAQEAHALIRSWVSSKIGADVAGELRIL YGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKAT Q Description Functional site 1) chain C residue 11 type sequence N description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 2) chain C residue 13 type sequence K description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 3) chain C residue 95 type sequence H description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 4) chain C residue 167 type sequence E description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 5) chain C residue 171 type sequence A description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 6) chain C residue 172 type sequence I description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 7) chain C residue 173 type sequence G description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 8) chain C residue 212 type sequence G description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 9) chain C residue 213 type sequence S description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 10) chain C residue 234 type sequence G description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 11) chain C residue 235 type sequence G description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 12) chain C residue 131 type sequence L description BINDING SITE FOR RESIDUE CL C1252 source : AC4 13) chain C residue 170 type sequence W description BINDING SITE FOR RESIDUE CL C1252 source : AC4 14) chain C residue 52 type sequence K description BINDING SITE FOR RESIDUE CL A1252 source : AC6 15) chain C residue 86 type sequence F description BINDING SITE FOR RESIDUE CL A1252 source : AC6 16) chain C residue 103 type ACT_SITE sequence G description Electrophile source Swiss-Prot : SWS_FT_FI1 17) chain C residue 175 type ACT_SITE sequence G description Proton acceptor source Swiss-Prot : SWS_FT_FI2 18) chain C residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 19) chain C residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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