eF-site ID 2v2h-B PDB Code 2v2h Chain B click to enlarge Title The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL Source (TPIS_TRYBB) Sequence B:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV WAIGTGKVLTPQQAQEAHALIRSWVSSKIGADVAGELRIL YGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKAT Q Description Functional site 1) chain B residue 11 type sequence N description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 2) chain B residue 13 type sequence K description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 3) chain B residue 95 type sequence H description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 4) chain B residue 167 type sequence E description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 5) chain B residue 171 type sequence A description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 6) chain B residue 172 type sequence I description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 7) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 8) chain B residue 212 type sequence G description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 9) chain B residue 213 type sequence S description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 10) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 11) chain B residue 235 type sequence G description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 12) chain B residue 52 type sequence K description BINDING SITE FOR RESIDUE CL C1252 source : AC4 13) chain B residue 86 type sequence F description BINDING SITE FOR RESIDUE CL C1252 source : AC4 14) chain B residue 131 type sequence L description BINDING SITE FOR RESIDUE CL B1252 source : AC5 15) chain B residue 170 type sequence W description BINDING SITE FOR RESIDUE CL B1252 source : AC5 16) chain B residue 103 type ACT_SITE sequence G description Electrophile source Swiss-Prot : SWS_FT_FI1 17) chain B residue 175 type ACT_SITE sequence G description Proton acceptor source Swiss-Prot : SWS_FT_FI2 18) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 19) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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