eF-site ID 2v2h-ABC
PDB Code 2v2h
Chain A, B, C

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Title The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM
Classification ISOMERASE
Compound TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL
Source (TPIS_TRYBB)
Sequence A:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA
STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN
WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE
TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV
WAIGTGKVLTPQQAQEAHALIRSWVSSKIGADVAGELRIL
YGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKAT
Q
B:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA
STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN
WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE
TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV
WAIGTGKVLTPQQAQEAHALIRSWVSSKIGADVAGELRIL
YGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKAT
Q
C:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA
STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN
WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE
TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV
WAIGTGKVLTPQQAQEAHALIRSWVSSKIGADVAGELRIL
YGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKAT
Q
Description


Functional site

1) chain A
residue 11
type
sequence N
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

2) chain A
residue 13
type
sequence K
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

3) chain A
residue 95
type
sequence H
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

4) chain A
residue 167
type
sequence E
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

5) chain A
residue 171
type
sequence A
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

6) chain A
residue 172
type
sequence I
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

7) chain A
residue 173
type
sequence G
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

8) chain A
residue 212
type
sequence G
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

9) chain A
residue 213
type
sequence S
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

10) chain A
residue 234
type
sequence G
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

11) chain A
residue 235
type
sequence G
description BINDING SITE FOR RESIDUE PGA A1251
source : AC1

12) chain B
residue 11
type
sequence N
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

13) chain B
residue 13
type
sequence K
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

14) chain B
residue 95
type
sequence H
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

15) chain B
residue 167
type
sequence E
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

16) chain B
residue 171
type
sequence A
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

17) chain B
residue 172
type
sequence I
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

18) chain B
residue 173
type
sequence G
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

19) chain B
residue 212
type
sequence G
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

20) chain B
residue 213
type
sequence S
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

21) chain B
residue 234
type
sequence G
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

22) chain B
residue 235
type
sequence G
description BINDING SITE FOR RESIDUE PGA B1251
source : AC2

23) chain C
residue 11
type
sequence N
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

24) chain C
residue 13
type
sequence K
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

25) chain C
residue 95
type
sequence H
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

26) chain C
residue 167
type
sequence E
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

27) chain C
residue 171
type
sequence A
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

28) chain C
residue 172
type
sequence I
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

29) chain C
residue 173
type
sequence G
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

30) chain C
residue 212
type
sequence G
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

31) chain C
residue 213
type
sequence S
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

32) chain C
residue 234
type
sequence G
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

33) chain C
residue 235
type
sequence G
description BINDING SITE FOR RESIDUE PGA C1251
source : AC3

34) chain B
residue 52
type
sequence K
description BINDING SITE FOR RESIDUE CL C1252
source : AC4

35) chain B
residue 86
type
sequence F
description BINDING SITE FOR RESIDUE CL C1252
source : AC4

36) chain C
residue 131
type
sequence L
description BINDING SITE FOR RESIDUE CL C1252
source : AC4

37) chain C
residue 170
type
sequence W
description BINDING SITE FOR RESIDUE CL C1252
source : AC4

38) chain A
residue 52
type
sequence K
description BINDING SITE FOR RESIDUE CL B1252
source : AC5

39) chain A
residue 86
type
sequence F
description BINDING SITE FOR RESIDUE CL B1252
source : AC5

40) chain B
residue 131
type
sequence L
description BINDING SITE FOR RESIDUE CL B1252
source : AC5

41) chain B
residue 170
type
sequence W
description BINDING SITE FOR RESIDUE CL B1252
source : AC5

42) chain A
residue 131
type
sequence L
description BINDING SITE FOR RESIDUE CL A1252
source : AC6

43) chain C
residue 52
type
sequence K
description BINDING SITE FOR RESIDUE CL A1252
source : AC6

44) chain C
residue 86
type
sequence F
description BINDING SITE FOR RESIDUE CL A1252
source : AC6

45) chain A
residue 165-175
type prosite
sequence AYEPVWAIGTG
description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG
source prosite : PS00171

46) chain A
residue 95
type ACT_SITE
sequence H
description Electrophile
source Swiss-Prot : SWS_FT_FI1

47) chain B
residue 95
type ACT_SITE
sequence H
description Electrophile
source Swiss-Prot : SWS_FT_FI1

48) chain C
residue 95
type ACT_SITE
sequence H
description Electrophile
source Swiss-Prot : SWS_FT_FI1

49) chain A
residue 167
type ACT_SITE
sequence E
description Proton acceptor
source Swiss-Prot : SWS_FT_FI2

50) chain B
residue 167
type ACT_SITE
sequence E
description Proton acceptor
source Swiss-Prot : SWS_FT_FI2

51) chain C
residue 167
type ACT_SITE
sequence E
description Proton acceptor
source Swiss-Prot : SWS_FT_FI2

52) chain A
residue 11
type BINDING
sequence N
description
source Swiss-Prot : SWS_FT_FI3

53) chain A
residue 13
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3

54) chain B
residue 11
type BINDING
sequence N
description
source Swiss-Prot : SWS_FT_FI3

55) chain B
residue 13
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3

56) chain C
residue 11
type BINDING
sequence N
description
source Swiss-Prot : SWS_FT_FI3

57) chain C
residue 13
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3


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