eF-site ID 2v2h-ABC PDB Code 2v2h Chain A, B, C click to enlarge Title The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL Source (TPIS_TRYBB) Sequence A:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV WAIGTGKVLTPQQAQEAHALIRSWVSSKIGADVAGELRIL YGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKAT Q B:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV WAIGTGKVLTPQQAQEAHALIRSWVSSKIGADVAGELRIL YGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKAT Q C:  SKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVVA STFVHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVN WIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIGE TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV WAIGTGKVLTPQQAQEAHALIRSWVSSKIGADVAGELRIL YGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKAT Q Description Functional site 1) chain A residue 11 type sequence N description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 2) chain A residue 13 type sequence K description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 3) chain A residue 95 type sequence H description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 4) chain A residue 167 type sequence E description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 5) chain A residue 171 type sequence A description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 6) chain A residue 172 type sequence I description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 7) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 8) chain A residue 212 type sequence G description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 9) chain A residue 213 type sequence S description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 10) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 11) chain A residue 235 type sequence G description BINDING SITE FOR RESIDUE PGA A1251 source : AC1 12) chain B residue 11 type sequence N description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 13) chain B residue 13 type sequence K description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 14) chain B residue 95 type sequence H description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 15) chain B residue 167 type sequence E description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 16) chain B residue 171 type sequence A description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 17) chain B residue 172 type sequence I description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 18) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 19) chain B residue 212 type sequence G description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 20) chain B residue 213 type sequence S description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 21) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 22) chain B residue 235 type sequence G description BINDING SITE FOR RESIDUE PGA B1251 source : AC2 23) chain C residue 11 type sequence N description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 24) chain C residue 13 type sequence K description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 25) chain C residue 95 type sequence H description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 26) chain C residue 167 type sequence E description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 27) chain C residue 171 type sequence A description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 28) chain C residue 172 type sequence I description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 29) chain C residue 173 type sequence G description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 30) chain C residue 212 type sequence G description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 31) chain C residue 213 type sequence S description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 32) chain C residue 234 type sequence G description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 33) chain C residue 235 type sequence G description BINDING SITE FOR RESIDUE PGA C1251 source : AC3 34) chain B residue 52 type sequence K description BINDING SITE FOR RESIDUE CL C1252 source : AC4 35) chain B residue 86 type sequence F description BINDING SITE FOR RESIDUE CL C1252 source : AC4 36) chain C residue 131 type sequence L description BINDING SITE FOR RESIDUE CL C1252 source : AC4 37) chain C residue 170 type sequence W description BINDING SITE FOR RESIDUE CL C1252 source : AC4 38) chain A residue 52 type sequence K description BINDING SITE FOR RESIDUE CL B1252 source : AC5 39) chain A residue 86 type sequence F description BINDING SITE FOR RESIDUE CL B1252 source : AC5 40) chain B residue 131 type sequence L description BINDING SITE FOR RESIDUE CL B1252 source : AC5 41) chain B residue 170 type sequence W description BINDING SITE FOR RESIDUE CL B1252 source : AC5 42) chain A residue 131 type sequence L description BINDING SITE FOR RESIDUE CL A1252 source : AC6 43) chain C residue 52 type sequence K description BINDING SITE FOR RESIDUE CL A1252 source : AC6 44) chain C residue 86 type sequence F description BINDING SITE FOR RESIDUE CL A1252 source : AC6 45) chain A residue 165-175 type prosite sequence AYEPVWAIGTG description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG source prosite : PS00171 46) chain A residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 47) chain B residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 48) chain C residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 49) chain A residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 50) chain B residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 51) chain C residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2 52) chain A residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 53) chain A residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 54) chain B residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 55) chain B residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 56) chain C residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 57) chain C residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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