eF-site ID 2v22-D PDB Code 2v22 Chain D click to enlarge Title REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors Classification TRANSFERASE Compound CELL DIVISION PROTEIN KINASE 2 Source (CCNA2_HUMAN) Sequence D:  VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAIL VDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAM FLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK NSKYHGVSLLNPPETLNL Description Functional site 1) chain D residue 210 type sequence M description BINDING SITE FOR RESIDUE C35 D1433 source : AC2 2) chain D residue 214 type sequence L description BINDING SITE FOR RESIDUE C35 D1433 source : AC2 3) chain D residue 217 type sequence W description BINDING SITE FOR RESIDUE C35 D1433 source : AC2 4) chain D residue 250 type sequence R description BINDING SITE FOR RESIDUE C35 D1433 source : AC2 5) chain D residue 254 type sequence Q description BINDING SITE FOR RESIDUE C35 D1433 source : AC2 6) chain D residue 281 type sequence I description BINDING SITE FOR RESIDUE C35 D1433 source : AC2 7) chain D residue 282 type sequence T description BINDING SITE FOR RESIDUE C35 D1433 source : AC2 8) chain D residue 283 type sequence D description BINDING SITE FOR RESIDUE C35 D1433 source : AC2 9) chain D residue 285 type sequence T description BINDING SITE FOR RESIDUE C35 D1433 source : AC2

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