eF-site ID 2v16-CO PDB Code 2v16 Chain C, O click to enlarge Title Crystal Structure of Renin with Inhibitor 3 Classification HYDROLASE Compound RENIN Source (RENI_HUMAN) Sequence C:  GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSN VWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY STGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAE FDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYN RDSESLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMK GVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEAL GAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVF QESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTE FDRRNNRIGFALAR O:  NTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNV WVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYS TGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEF DGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNR DSSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGV SVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGA KKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQE SYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFD RRNNRIGFALAR Description (1)  RENIN (E.C.3.4.23.15) Functional site 1) chain C residue 12 type sequence T description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 2) chain C residue 13 type sequence Q description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 3) chain C residue 30 type sequence V description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 4) chain C residue 32 type sequence D description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 5) chain C residue 34 type sequence G description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 6) chain C residue 35 type sequence S description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 7) chain C residue 74 type sequence R description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 8) chain C residue 75 type sequence Y description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 9) chain C residue 76 type sequence S description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 10) chain C residue 77 type sequence T description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 11) chain C residue 111 type sequence P description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 12) chain C residue 117 type sequence F description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 13) chain C residue 215 type sequence D description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 14) chain C residue 216 type sequence T description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 15) chain C residue 217 type sequence G description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 16) chain C residue 218 type sequence A description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 17) chain C residue 219 type sequence S description BINDING SITE FOR RESIDUE C47 C1327 source : AC1 18) chain O residue 12 type sequence T description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 19) chain O residue 13 type sequence Q description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 20) chain O residue 32 type sequence D description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 21) chain O residue 34 type sequence G description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 22) chain O residue 35 type sequence S description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 23) chain O residue 74 type sequence R description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 24) chain O residue 75 type sequence Y description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 25) chain O residue 76 type sequence S description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 26) chain O residue 77 type sequence T description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 27) chain O residue 111 type sequence P description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 28) chain O residue 114 type sequence L description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 29) chain O residue 115 type sequence A description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 30) chain O residue 130 type sequence I description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 31) chain O residue 215 type sequence D description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 32) chain O residue 216 type sequence T description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 33) chain O residue 217 type sequence G description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 34) chain O residue 218 type sequence A description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 35) chain O residue 219 type sequence S description BINDING SITE FOR RESIDUE C47 O1327 source : AC2 36) chain C residue 29-40 type prosite sequence VVFDTGSSNVWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 37) chain C residue 212-223 type prosite sequence ALVDTGASYISG description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 38) chain C residue 32 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 39) chain C residue 215 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 40) chain O residue 32 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 41) chain O residue 215 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 42) chain C residue -1 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 43) chain C residue 67 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 44) chain O residue -1 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 45) chain O residue 67 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2

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