eF-site ID 2v13-A PDB Code 2v13 Chain A click to enlarge Title Crystal Structure of Renin with Inhibitor 7 Classification HYDROLASE Compound RENIN Source (RENI_HUMAN) Sequence A:  NTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNV WVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYS TGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEF DGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNR DLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSV GSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKK RLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESY SSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRR NNRIGFALAR Description (1)  RENIN (E.C.3.4.23.15) Functional site 1) chain A residue 19 type sequence Q description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 2) chain A residue 20 type sequence Y description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 3) chain A residue 38 type sequence D description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 4) chain A residue 40 type sequence G description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 5) chain A residue 82 type sequence R description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 6) chain A residue 83 type sequence Y description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 7) chain A residue 84 type sequence S description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 8) chain A residue 85 type sequence T description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 9) chain A residue 118 type sequence P description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 10) chain A residue 137 type sequence I description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 11) chain A residue 226 type sequence D description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 12) chain A residue 227 type sequence T description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 13) chain A residue 228 type sequence G description BINDING SITE FOR RESIDUE C40 A1341 source : AC1 14) chain A residue 35-46 type prosite sequence VVFDTGSSNVWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 15) chain A residue 223-234 type prosite sequence ALVDTGASYISG description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 16) chain A residue 38 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 226 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 5 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 75 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2

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