eF-site ID 2v12-CO PDB Code 2v12 Chain C, O click to enlarge Title Crystal Structure of Renin with Inhibitor 8 Classification HYDROLASE Compound RENIN Source (RENI_HUMAN) Sequence C:  GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSN VWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY STGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAE FDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYN RDSESLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMK GVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEAL GAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVF QESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTE FDRRNNRIGFALAR O:  NTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNV WVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYS TGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEF DGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNR DSSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGV SVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGA KKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQE SYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFD RRNNRIGFALAR Description (1)  RENIN (E.C.3.4.23.15) Functional site 1) chain C residue 18 type sequence T description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 2) chain C residue 20 type sequence Y description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 3) chain C residue 38 type sequence D description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 4) chain C residue 40 type sequence G description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 5) chain C residue 41 type sequence S description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 6) chain C residue 42 type sequence S description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 7) chain C residue 43 type sequence N description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 8) chain C residue 82 type sequence R description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 9) chain C residue 83 type sequence Y description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 10) chain C residue 84 type sequence S description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 11) chain C residue 85 type sequence T description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 12) chain C residue 122 type sequence A description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 13) chain C residue 124 type sequence F description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 14) chain C residue 127 type sequence V description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 15) chain C residue 135 type sequence Q description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 16) chain C residue 226 type sequence D description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 17) chain C residue 227 type sequence T description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 18) chain C residue 228 type sequence G description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 19) chain C residue 229 type sequence A description BINDING SITE FOR RESIDUE C39 C 350 source : AC1 20) chain O residue 19 type sequence Q description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 21) chain O residue 20 type sequence Y description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 22) chain O residue 36 type sequence V description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 23) chain O residue 38 type sequence D description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 24) chain O residue 40 type sequence G description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 25) chain O residue 41 type sequence S description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 26) chain O residue 82 type sequence R description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 27) chain O residue 84 type sequence S description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 28) chain O residue 85 type sequence T description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 29) chain O residue 118 type sequence P description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 30) chain O residue 122 type sequence A description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 31) chain O residue 127 type sequence V description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 32) chain O residue 226 type sequence D description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 33) chain O residue 227 type sequence T description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 34) chain O residue 228 type sequence G description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 35) chain O residue 229 type sequence A description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 36) chain C residue 35-46 type prosite sequence VVFDTGSSNVWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 37) chain C residue 223-234 type prosite sequence ALVDTGASYISG description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 38) chain C residue 38 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 39) chain C residue 226 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 40) chain O residue 38 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 41) chain O residue 226 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 42) chain C residue 5 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 43) chain C residue 75 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 44) chain O residue 5 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 45) chain O residue 75 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2

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