eF-site ID 2v12-O PDB Code 2v12 Chain O click to enlarge Title Crystal Structure of Renin with Inhibitor 8 Classification HYDROLASE Compound RENIN Source (RENI_HUMAN) Sequence O:  NTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNV WVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYS TGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEF DGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNR DSSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGV SVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGA KKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQE SYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFD RRNNRIGFALAR Description (1)  RENIN (E.C.3.4.23.15) Functional site 1) chain O residue 19 type sequence Q description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 2) chain O residue 20 type sequence Y description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 3) chain O residue 36 type sequence V description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 4) chain O residue 38 type sequence D description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 5) chain O residue 40 type sequence G description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 6) chain O residue 41 type sequence S description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 7) chain O residue 82 type sequence R description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 8) chain O residue 84 type sequence S description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 9) chain O residue 85 type sequence T description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 10) chain O residue 118 type sequence P description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 11) chain O residue 122 type sequence A description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 12) chain O residue 127 type sequence V description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 13) chain O residue 226 type sequence D description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 14) chain O residue 227 type sequence T description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 15) chain O residue 228 type sequence G description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 16) chain O residue 229 type sequence A description BINDING SITE FOR RESIDUE C39 O 350 source : AC2 17) chain O residue 38 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 18) chain O residue 226 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 19) chain O residue 5 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 20) chain O residue 75 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2

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