eF-site ID 2v10-CO PDB Code 2v10 Chain C, O click to enlarge Title Crystal Structure of Renin with Inhibitor 9 Classification HYDROLASE Compound RENIN Source (RENI_HUMAN) Sequence C:  GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSN VWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY STGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAE FDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYN RDSESLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMK GVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEAL GAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVF QESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTE FDRRNNRIGFALAR O:  NTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNV WVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYS TGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEF DGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNR DSSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGV SVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGA KKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQE SYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFD RRNNRIGFALAR Description (1)  RENIN (E.C.3.4.23.15) Functional site 1) chain C residue 18 type sequence T description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 2) chain C residue 19 type sequence Q description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 3) chain C residue 20 type sequence Y description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 4) chain C residue 36 type sequence V description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 5) chain C residue 38 type sequence D description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 6) chain C residue 40 type sequence G description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 7) chain C residue 82 type sequence R description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 8) chain C residue 83 type sequence Y description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 9) chain C residue 84 type sequence S description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 10) chain C residue 118 type sequence P description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 11) chain C residue 127 type sequence V description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 12) chain C residue 226 type sequence D description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 13) chain C residue 227 type sequence T description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 14) chain C residue 228 type sequence G description BINDING SITE FOR RESIDUE C61 C1341 source : AC1 15) chain O residue 19 type sequence Q description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 16) chain O residue 20 type sequence Y description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 17) chain O residue 36 type sequence V description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 18) chain O residue 38 type sequence D description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 19) chain O residue 40 type sequence G description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 20) chain O residue 82 type sequence R description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 21) chain O residue 83 type sequence Y description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 22) chain O residue 84 type sequence S description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 23) chain O residue 85 type sequence T description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 24) chain O residue 122 type sequence A description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 25) chain O residue 137 type sequence I description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 26) chain O residue 162 type sequence Y description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 27) chain O residue 226 type sequence D description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 28) chain O residue 227 type sequence T description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 29) chain O residue 228 type sequence G description BINDING SITE FOR RESIDUE C61 O1341 source : AC2 30) chain C residue 38 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 31) chain C residue 226 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 32) chain O residue 38 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 33) chain O residue 226 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:20927107 source Swiss-Prot : SWS_FT_FI1 34) chain C residue 5 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 35) chain C residue 75 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 36) chain O residue 5 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 37) chain O residue 75 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678 source Swiss-Prot : SWS_FT_FI2 38) chain C residue 35-46 type prosite sequence VVFDTGSSNVWV description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141 39) chain C residue 223-234 type prosite sequence ALVDTGASYISG description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV source prosite : PS00141

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