eF-site ID 2v0t-E PDB Code 2v0t Chain E click to enlarge Title The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM Classification ISOMERASE Compound TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL Source (TPIS_TRYBB) Sequence E:  SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK VVIAYEPVWAVLTPQQAQEAHALIRSWVSSKIGADVAGEL RILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDII KATQ Description Functional site 1) chain E residue 213 type sequence S description BINDING SITE FOR RESIDUE SO4 E1251 source : AC5 2) chain E residue 234 type sequence G description BINDING SITE FOR RESIDUE SO4 E1251 source : AC5 3) chain E residue 235 type sequence G description BINDING SITE FOR RESIDUE SO4 E1251 source : AC5 4) chain E residue 31 type sequence T description BINDING SITE FOR RESIDUE SO4 E1252 source : BC1 5) chain E residue 32 type sequence S description BINDING SITE FOR RESIDUE SO4 E1252 source : BC1 6) chain E residue 33 type sequence I description BINDING SITE FOR RESIDUE SO4 E1252 source : BC1 7) chain E residue 57 type sequence H description BINDING SITE FOR RESIDUE SO4 E1252 source : BC1 8) chain E residue 13 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 9) chain E residue 11 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 10) chain E residue 95 type ACT_SITE sequence H description Electrophile source Swiss-Prot : SWS_FT_FI1 11) chain E residue 167 type ACT_SITE sequence E description Proton acceptor source Swiss-Prot : SWS_FT_FI2

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