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eF-site ID
|
2v0t-C |
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PDB Code
|
2v0t |
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Chain
|
C |
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click to enlarge
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Title
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The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM |
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Classification
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ISOMERASE |
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Compound
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TRIOSEPHOSPHATE ISOMERASE GLYCOSOMAL |
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Source
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(TPIS_TRYBB) |
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Sequence
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C: |
SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVV
ASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLP
ILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGF
MVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAK
VVIAYEPVWLTPQQAQEAHALIRSWVSSKIGADVAGELRI
LYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKA
TQ
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Description
|
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Functional site
|
|
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1)
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chain |
C |
| residue |
170 |
| type |
|
| sequence |
W
|
| description |
BINDING SITE FOR RESIDUE SO4 C1251
|
| source |
: AC3
|
|
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2)
|
chain |
C |
| residue |
213 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE SO4 C1251
|
| source |
: AC3
|
|
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3)
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chain |
C |
| residue |
234 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE SO4 C1251
|
| source |
: AC3
|
|
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4)
|
chain |
C |
| residue |
235 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE SO4 C1251
|
| source |
: AC3
|
|
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5)
|
chain |
C |
| residue |
155 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE EPE C1252
|
| source |
: BC2
|
|
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6)
|
chain |
C |
| residue |
95 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Electrophile
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
C |
| residue |
167 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
C |
| residue |
11 |
| type |
BINDING |
| sequence |
N
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
9)
|
chain |
C |
| residue |
13 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|