eF-site ID 2v0g-D PDB Code 2v0g Chain D click to enlarge Title LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A tRNA(leu) transcript with 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) forming an adduct to the ribose of adenosine- 76 in the enzyme editing site. Classification LIGASE Compound AMINOACYL-TRNA SYNTHETASE Source null (2V0G) Sequence D:  MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVM FPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWD AFGLPAENAALKFGVHPKDWTYANIRQAKESLRLMGILYD WDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCP KCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYA ERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKE VRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEV LAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERI PIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKK VIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRK VIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCE ACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFY ETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLP FDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLG MVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTR IRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSK SKGNGVMVGPFVKEQGADIARITILFAAPPENEMVWTEEG VQGAWRFLNRIYRRVAEDREALLETSGVFQAEALEGKDRE LYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRK DRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLF EAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLE VARAEALKVRNVRAHLEGKEVVKEIYVPGKILNLVV Description Functional site 1) chain D residue 706 type sequence S description BINDING SITE FOR RESIDUE SO4 D1877 source : BC2 2) chain D residue 707 type sequence G description BINDING SITE FOR RESIDUE SO4 D1877 source : BC2 3) chain D residue 708 type sequence V description BINDING SITE FOR RESIDUE SO4 D1877 source : BC2 4) chain D residue 769 type sequence R description BINDING SITE FOR RESIDUE SO4 D1877 source : BC2 5) chain D residue 773 type sequence R description BINDING SITE FOR RESIDUE SO4 D1877 source : BC2 6) chain D residue 795 type sequence W description BINDING SITE FOR RESIDUE SO4 D1877 source : BC2 7) chain D residue 759 type sequence R description BINDING SITE FOR RESIDUE SO4 D1878 source : BC3 8) chain D residue 264 type sequence E description BINDING SITE FOR RESIDUE SO4 D1879 source : BC4 9) chain D residue 330 type sequence F description BINDING SITE FOR RESIDUE SO4 D1879 source : BC4 10) chain D residue 331 type sequence G description BINDING SITE FOR RESIDUE SO4 D1879 source : BC4 11) chain D residue 420 type sequence R description BINDING SITE FOR RESIDUE SO4 D1879 source : BC4 12) chain D residue 439 type sequence C description BINDING SITE FOR RESIDUE ZN D1880 source : BC5 13) chain D residue 484 type sequence C description BINDING SITE FOR RESIDUE ZN D1880 source : BC5 14) chain D residue 487 type sequence C description BINDING SITE FOR RESIDUE ZN D1880 source : BC5 15) chain D residue 159 type sequence C description BINDING SITE FOR RESIDUE ZN D1881 source : BC6 16) chain D residue 162 type sequence C description BINDING SITE FOR RESIDUE ZN D1881 source : BC6 17) chain D residue 176 type sequence C description BINDING SITE FOR RESIDUE ZN D1881 source : BC6 18) chain D residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN D1881 source : BC6 19) chain D residue 128 type sequence C description BINDING SITE FOR RESIDUE HG D1882 source : BC7 20) chain D residue 129 type sequence E description BINDING SITE FOR RESIDUE HG D1882 source : BC7 21) chain D residue 41 type sequence F description BINDING SITE FOR RESIDUE LEU D1883 source : BC9 22) chain D residue 42 type sequence P description BINDING SITE FOR RESIDUE LEU D1883 source : BC9 23) chain D residue 43 type sequence Y description BINDING SITE FOR RESIDUE LEU D1883 source : BC9 24) chain D residue 541 type sequence H description BINDING SITE FOR RESIDUE LEU D1883 source : BC9

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