eF-site ID 2v0g-AD
PDB Code 2v0g
Chain A, D

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Title LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A tRNA(leu) transcript with 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) forming an adduct to the ribose of adenosine- 76 in the enzyme editing site.
Classification LIGASE
Compound AMINOACYL-TRNA SYNTHETASE
Source Thermus thermophilus (2V0G)
Sequence A:  MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVM
FPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWD
AFGLPAENAALKFGVHPKDWTYANIRQAKESLRLMGILYD
WDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCP
KCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYA
ERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKE
VRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEV
LAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERI
PIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKK
VIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRK
VIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCE
ACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFY
ETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLP
FDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLG
MVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTR
IRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSK
SKGNGVMVGPFVKEQGADIARITILFAAPPENEMVWTEEG
VQGAWRFLNRIYRRVAEDREALLETSGVFQAEALEGKDRE
LYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRK
DRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLF
EAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLE
VARAEALKVRNVRAHLEGKEVVKEIYVPGKILNLVV
D:  MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVM
FPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWD
AFGLPAENAALKFGVHPKDWTYANIRQAKESLRLMGILYD
WDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCP
KCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYA
ERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKE
VRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEV
LAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERI
PIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKK
VIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRK
VIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCE
ACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFY
ETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLP
FDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLG
MVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTR
IRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSK
SKGNGVMVGPFVKEQGADIARITILFAAPPENEMVWTEEG
VQGAWRFLNRIYRRVAEDREALLETSGVFQAEALEGKDRE
LYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRK
DRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLF
EAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLE
VARAEALKVRNVRAHLEGKEVVKEIYVPGKILNLVV
Description


Functional site

1) chain A
residue 439
type
sequence C
description BINDING SITE FOR RESIDUE ZN A1877
source : AC1

2) chain A
residue 442
type
sequence C
description BINDING SITE FOR RESIDUE ZN A1877
source : AC1

3) chain A
residue 484
type
sequence C
description BINDING SITE FOR RESIDUE ZN A1877
source : AC1

4) chain A
residue 487
type
sequence C
description BINDING SITE FOR RESIDUE ZN A1877
source : AC1

5) chain A
residue 159
type
sequence C
description BINDING SITE FOR RESIDUE ZN A1878
source : AC2

6) chain A
residue 162
type
sequence C
description BINDING SITE FOR RESIDUE ZN A1878
source : AC2

7) chain A
residue 176
type
sequence C
description BINDING SITE FOR RESIDUE ZN A1878
source : AC2

8) chain A
residue 179
type
sequence H
description BINDING SITE FOR RESIDUE ZN A1878
source : AC2

9) chain A
residue 102
type
sequence Y
description BINDING SITE FOR RESIDUE HG A1879
source : AC3

10) chain A
residue 128
type
sequence C
description BINDING SITE FOR RESIDUE HG A1879
source : AC3

11) chain A
residue 129
type
sequence E
description BINDING SITE FOR RESIDUE HG A1879
source : AC3

12) chain A
residue 762
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1880
source : AC4

13) chain A
residue 707
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A1881
source : AC5

14) chain A
residue 769
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1881
source : AC5

15) chain A
residue 795
type
sequence W
description BINDING SITE FOR RESIDUE SO4 A1881
source : AC5

16) chain A
residue 49
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A1882
source : AC6

17) chain A
residue 52
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A1882
source : AC6

18) chain A
residue 639
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A1882
source : AC6

19) chain A
residue 640
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A1882
source : AC6

20) chain A
residue 759
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1883
source : AC7

21) chain A
residue 288
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A1884
source : AC8

22) chain A
residue 32
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1885
source : AC9

23) chain A
residue 69
type
sequence Q
description BINDING SITE FOR RESIDUE SO4 A1885
source : AC9

24) chain A
residue 70
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A1885
source : AC9

25) chain A
residue 71
type
sequence Y
description BINDING SITE FOR RESIDUE SO4 A1885
source : AC9

26) chain A
residue 264
type
sequence E
description BINDING SITE FOR RESIDUE SO4 A1886
source : BC1

27) chain A
residue 329
type
sequence L
description BINDING SITE FOR RESIDUE SO4 A1886
source : BC1

28) chain A
residue 330
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A1886
source : BC1

29) chain A
residue 331
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A1886
source : BC1

30) chain A
residue 420
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A1886
source : BC1

31) chain D
residue 706
type
sequence S
description BINDING SITE FOR RESIDUE SO4 D1877
source : BC2

32) chain D
residue 707
type
sequence G
description BINDING SITE FOR RESIDUE SO4 D1877
source : BC2

33) chain D
residue 708
type
sequence V
description BINDING SITE FOR RESIDUE SO4 D1877
source : BC2

34) chain D
residue 769
type
sequence R
description BINDING SITE FOR RESIDUE SO4 D1877
source : BC2

35) chain D
residue 773
type
sequence R
description BINDING SITE FOR RESIDUE SO4 D1877
source : BC2

36) chain D
residue 795
type
sequence W
description BINDING SITE FOR RESIDUE SO4 D1877
source : BC2

37) chain D
residue 759
type
sequence R
description BINDING SITE FOR RESIDUE SO4 D1878
source : BC3

38) chain D
residue 264
type
sequence E
description BINDING SITE FOR RESIDUE SO4 D1879
source : BC4

39) chain D
residue 330
type
sequence F
description BINDING SITE FOR RESIDUE SO4 D1879
source : BC4

40) chain D
residue 331
type
sequence G
description BINDING SITE FOR RESIDUE SO4 D1879
source : BC4

41) chain D
residue 420
type
sequence R
description BINDING SITE FOR RESIDUE SO4 D1879
source : BC4

42) chain D
residue 439
type
sequence C
description BINDING SITE FOR RESIDUE ZN D1880
source : BC5

43) chain D
residue 484
type
sequence C
description BINDING SITE FOR RESIDUE ZN D1880
source : BC5

44) chain D
residue 487
type
sequence C
description BINDING SITE FOR RESIDUE ZN D1880
source : BC5

45) chain D
residue 159
type
sequence C
description BINDING SITE FOR RESIDUE ZN D1881
source : BC6

46) chain D
residue 162
type
sequence C
description BINDING SITE FOR RESIDUE ZN D1881
source : BC6

47) chain D
residue 176
type
sequence C
description BINDING SITE FOR RESIDUE ZN D1881
source : BC6

48) chain D
residue 179
type
sequence H
description BINDING SITE FOR RESIDUE ZN D1881
source : BC6

49) chain D
residue 128
type
sequence C
description BINDING SITE FOR RESIDUE HG D1882
source : BC7

50) chain D
residue 129
type
sequence E
description BINDING SITE FOR RESIDUE HG D1882
source : BC7

51) chain A
residue 40
type
sequence M
description BINDING SITE FOR RESIDUE LEU A1887
source : BC8

52) chain A
residue 41
type
sequence F
description BINDING SITE FOR RESIDUE LEU A1887
source : BC8

53) chain A
residue 43
type
sequence Y
description BINDING SITE FOR RESIDUE LEU A1887
source : BC8

54) chain A
residue 80
type
sequence D
description BINDING SITE FOR RESIDUE LEU A1887
source : BC8

55) chain A
residue 504
type
sequence S
description BINDING SITE FOR RESIDUE LEU A1887
source : BC8

56) chain A
residue 535
type
sequence Y
description BINDING SITE FOR RESIDUE LEU A1887
source : BC8

57) chain A
residue 541
type
sequence H
description BINDING SITE FOR RESIDUE LEU A1887
source : BC8

58) chain A
residue 545
type
sequence H
description BINDING SITE FOR RESIDUE LEU A1887
source : BC8

59) chain D
residue 41
type
sequence F
description BINDING SITE FOR RESIDUE LEU D1883
source : BC9

60) chain D
residue 42
type
sequence P
description BINDING SITE FOR RESIDUE LEU D1883
source : BC9

61) chain D
residue 43
type
sequence Y
description BINDING SITE FOR RESIDUE LEU D1883
source : BC9

62) chain D
residue 541
type
sequence H
description BINDING SITE FOR RESIDUE LEU D1883
source : BC9

63) chain A
residue 42-53
type prosite
sequence PYPSGDLHMGHL
description AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PypSGdLHMGHL
source prosite : PS00178


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