eF-site ID 2v0g-A PDB Code 2v0g Chain A click to enlarge Title LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A tRNA(leu) transcript with 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) forming an adduct to the ribose of adenosine- 76 in the enzyme editing site. Classification LIGASE Compound AMINOACYL-TRNA SYNTHETASE Source Thermus thermophilus (2V0G) Sequence A:  MEKYNPHAIEAKWQRFWEEKGFMKAKDLPGGRGKQYVLVM FPYPSGDLHMGHLKNYTMGDVLARFRRMQGYEVLHPMGWD AFGLPAENAALKFGVHPKDWTYANIRQAKESLRLMGILYD WDREVTTCEPEYYRWNQWIFLKMWEKGLAYRAKGLVNWCP KCQTVLANEQVVEGRCWRHEDTPVEKRELEQWYLRITAYA ERLLKDLEGLNWPEKVKAMQRAWIGRSEGAEILFPVEGKE VRIPVFTTRPDTLFGATFLVLAPEHPLTLELAAPEKREEV LAYVEAAKRKTEIERQAEGREKTGVFLGAYALNPATGERI PIWTADYVLFGYGTGAIMAVPAHDQRDYEFARKFGLPIKK VIERPGEPLPEPLERAYEEPGIMVNSGPFDGTESEEGKRK VIAWLEEKGLGKGRVTYRLRDWLISRQRYWGTPIPMVHCE ACGVVPVPEEELPVLLPDLKDVEDIRPKGKSPLEAHPEFY ETTCPKCGGPAKRDTDTMDTFFDSSWYYLRYTDPHNDRLP FDPEKANAWMPVDQYIGGVEHAVLHLLYSRFFTKFLHDLG MVKVEEPFQGLFTQGMVLAWTDFGPVEVEGSVVRLPEPTR IRLEIPESALSLEDVRKMGAELRPHEDGTLHLWKPAVMSK SKGNGVMVGPFVKEQGADIARITILFAAPPENEMVWTEEG VQGAWRFLNRIYRRVAEDREALLETSGVFQAEALEGKDRE LYGKLHETLKKVTEDLEALRFNTAIAALMEFLNALYEYRK DRPVTPVYRTAIRYYLQMLFPFAPHLAEELWHWFWPDSLF EAGWPELDEKALEKDVVEVAVQVNGRVRGTIHIPKDAPLE VARAEALKVRNVRAHLEGKEVVKEIYVPGKILNLVV Description Functional site 1) chain A residue 439 type sequence C description BINDING SITE FOR RESIDUE ZN A1877 source : AC1 2) chain A residue 442 type sequence C description BINDING SITE FOR RESIDUE ZN A1877 source : AC1 3) chain A residue 484 type sequence C description BINDING SITE FOR RESIDUE ZN A1877 source : AC1 4) chain A residue 487 type sequence C description BINDING SITE FOR RESIDUE ZN A1877 source : AC1 5) chain A residue 159 type sequence C description BINDING SITE FOR RESIDUE ZN A1878 source : AC2 6) chain A residue 162 type sequence C description BINDING SITE FOR RESIDUE ZN A1878 source : AC2 7) chain A residue 176 type sequence C description BINDING SITE FOR RESIDUE ZN A1878 source : AC2 8) chain A residue 179 type sequence H description BINDING SITE FOR RESIDUE ZN A1878 source : AC2 9) chain A residue 102 type sequence Y description BINDING SITE FOR RESIDUE HG A1879 source : AC3 10) chain A residue 128 type sequence C description BINDING SITE FOR RESIDUE HG A1879 source : AC3 11) chain A residue 129 type sequence E description BINDING SITE FOR RESIDUE HG A1879 source : AC3 12) chain A residue 762 type sequence R description BINDING SITE FOR RESIDUE SO4 A1880 source : AC4 13) chain A residue 707 type sequence G description BINDING SITE FOR RESIDUE SO4 A1881 source : AC5 14) chain A residue 769 type sequence R description BINDING SITE FOR RESIDUE SO4 A1881 source : AC5 15) chain A residue 795 type sequence W description BINDING SITE FOR RESIDUE SO4 A1881 source : AC5 16) chain A residue 49 type sequence H description BINDING SITE FOR RESIDUE SO4 A1882 source : AC6 17) chain A residue 52 type sequence H description BINDING SITE FOR RESIDUE SO4 A1882 source : AC6 18) chain A residue 639 type sequence S description BINDING SITE FOR RESIDUE SO4 A1882 source : AC6 19) chain A residue 640 type sequence K description BINDING SITE FOR RESIDUE SO4 A1882 source : AC6 20) chain A residue 759 type sequence R description BINDING SITE FOR RESIDUE SO4 A1883 source : AC7 21) chain A residue 288 type sequence K description BINDING SITE FOR RESIDUE SO4 A1884 source : AC8 22) chain A residue 32 type sequence R description BINDING SITE FOR RESIDUE SO4 A1885 source : AC9 23) chain A residue 69 type sequence Q description BINDING SITE FOR RESIDUE SO4 A1885 source : AC9 24) chain A residue 70 type sequence G description BINDING SITE FOR RESIDUE SO4 A1885 source : AC9 25) chain A residue 71 type sequence Y description BINDING SITE FOR RESIDUE SO4 A1885 source : AC9 26) chain A residue 264 type sequence E description BINDING SITE FOR RESIDUE SO4 A1886 source : BC1 27) chain A residue 329 type sequence L description BINDING SITE FOR RESIDUE SO4 A1886 source : BC1 28) chain A residue 330 type sequence F description BINDING SITE FOR RESIDUE SO4 A1886 source : BC1 29) chain A residue 331 type sequence G description BINDING SITE FOR RESIDUE SO4 A1886 source : BC1 30) chain A residue 420 type sequence R description BINDING SITE FOR RESIDUE SO4 A1886 source : BC1 31) chain A residue 40 type sequence M description BINDING SITE FOR RESIDUE LEU A1887 source : BC8 32) chain A residue 41 type sequence F description BINDING SITE FOR RESIDUE LEU A1887 source : BC8 33) chain A residue 43 type sequence Y description BINDING SITE FOR RESIDUE LEU A1887 source : BC8 34) chain A residue 80 type sequence D description BINDING SITE FOR RESIDUE LEU A1887 source : BC8 35) chain A residue 504 type sequence S description BINDING SITE FOR RESIDUE LEU A1887 source : BC8 36) chain A residue 535 type sequence Y description BINDING SITE FOR RESIDUE LEU A1887 source : BC8 37) chain A residue 541 type sequence H description BINDING SITE FOR RESIDUE LEU A1887 source : BC8 38) chain A residue 545 type sequence H description BINDING SITE FOR RESIDUE LEU A1887 source : BC8 39) chain A residue 42-53 type prosite sequence PYPSGDLHMGHL description AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PypSGdLHMGHL source prosite : PS00178

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