eF-site ID 2uzi-HLR
PDB Code 2uzi
Chain H, L, R

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Title Crystal structure of HRAS(G12V) - anti-RAS Fv complex
Classification SIGNALING PROTEIN/IMMUNE SYSTEM
Compound ANTI-RAS FV HEAVY CHAIN
Source Homo sapiens (Human) (RASH_HUMAN)
Sequence H:  EVQLLESGGGLVQPGGSLRLSCAASGFTFSTFSMNWVRQA
PGKGLEWVSYISRTSKTIYYADSVKGRFTISRDNSKNTLY
LQMNSLRAEDTAVYYCARGRFFDYWGQGTLVTVS
L:  IQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPG
EAPKLLIYSASVLQSGVPSRFSGSGSGTDFTLTISSLQPE
DFATYYCQQSVMIPMTFGQGTKVE
R:  MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSY
RKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLC
VFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLV
REIRQH
Description


Functional site

1) chain H
residue 73
type
sequence D
description BINDING SITE FOR RESIDUE ZN H1115
source : AC1

2) chain H
residue 75
type
sequence S
description BINDING SITE FOR RESIDUE ZN H1115
source : AC1

3) chain H
residue 62
type
sequence D
description BINDING SITE FOR RESIDUE ZN H1116
source : AC2

4) chain R
residue 17
type
sequence S
description BINDING SITE FOR RESIDUE MG R1168
source : AC3

5) chain R
residue 35
type
sequence T
description BINDING SITE FOR RESIDUE MG R1168
source : AC3

6) chain R
residue 27
type
sequence H
description BINDING SITE FOR RESIDUE ZN R1169
source : AC4

7) chain R
residue 98
type
sequence E
description BINDING SITE FOR RESIDUE ZN R1169
source : AC4

8) chain R
residue 166
type
sequence H
description BINDING SITE FOR RESIDUE ZN R1170
source : AC5

9) chain H
residue 1
type
sequence E
description BINDING SITE FOR RESIDUE ZN R1171
source : AC6

10) chain R
residue 108
type
sequence D
description BINDING SITE FOR RESIDUE ZN R1171
source : AC6

11) chain R
residue 166
type
sequence H
description BINDING SITE FOR RESIDUE ZN R1171
source : AC6

12) chain R
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

13) chain R
residue 14
type
sequence V
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

14) chain R
residue 15
type
sequence G
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

15) chain R
residue 16
type
sequence K
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

16) chain R
residue 17
type
sequence S
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

17) chain R
residue 18
type
sequence A
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

18) chain R
residue 28
type
sequence F
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

19) chain R
residue 29
type
sequence V
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

20) chain R
residue 30
type
sequence D
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

21) chain R
residue 31
type
sequence E
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

22) chain R
residue 32
type
sequence Y
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

23) chain R
residue 34
type
sequence P
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

24) chain R
residue 35
type
sequence T
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

25) chain R
residue 60
type
sequence G
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

26) chain R
residue 116
type
sequence N
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

27) chain R
residue 117
type
sequence K
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

28) chain R
residue 119
type
sequence D
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

29) chain R
residue 145
type
sequence S
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

30) chain R
residue 146
type
sequence A
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

31) chain R
residue 147
type
sequence K
description BINDING SITE FOR RESIDUE GTP R1167
source : AC7

32) chain R
residue 1
type MOD_RES
sequence M
description N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12
source Swiss-Prot : SWS_FT_FI2

33) chain R
residue 2
type MOD_RES
sequence T
description N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12
source Swiss-Prot : SWS_FT_FI3

34) chain R
residue 118
type MOD_RES
sequence C
description S-nitrosocysteine => ECO:0000269|PubMed:9020151
source Swiss-Prot : SWS_FT_FI4

35) chain R
residue 13
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:16698776
source Swiss-Prot : SWS_FT_FI1

36) chain R
residue 29
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:16698776
source Swiss-Prot : SWS_FT_FI1

37) chain R
residue 59
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:16698776
source Swiss-Prot : SWS_FT_FI1

38) chain R
residue 116
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:16698776
source Swiss-Prot : SWS_FT_FI1

39) chain R
residue 145
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:16698776
source Swiss-Prot : SWS_FT_FI1

40) chain R
residue 35
type CARBOHYD
sequence T
description (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667
source Swiss-Prot : SWS_FT_FI5


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