|
|
eF-site ID
|
2uxn-E |
|
PDB Code
|
2uxn |
|
Chain
|
E |
|
click to enlarge
|
|
|
Title
|
Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation |
|
Classification
|
OXIDOREDUCTASE/TRANSCRIPTION REGULATOR |
|
Compound
|
LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 |
|
Source
|
null (H31_HUMAN) |
|
|
Sequence
|
E: |
ARTXQTA
|
|
|
Description
|
(1) |
LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 (E.C.1.-.-.-), REST COREPRESSOR 1, HISTONE H3.1
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
4 |
| type |
|
| sequence |
X
|
| description |
BINDING SITE FOR RESIDUE FDA A 900
|
| source |
: AC2
|
|
|
2)
|
chain |
E |
| residue |
2 |
| type |
MOD_RES |
| sequence |
R
|
| description |
Citrulline; alternate => ECO:0000269|PubMed:16567635
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
E |
| residue |
3 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
E |
| residue |
4 |
| type |
MOD_RES |
| sequence |
X
|
| description |
N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
E |
| residue |
5 |
| type |
MOD_RES |
| sequence |
Q
|
| description |
5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
6)
|
chain |
E |
| residue |
6 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|