eF-site ID 2uxn-A PDB Code 2uxn Chain A click to enlarge Title Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation Classification OXIDOREDUCTASE/TRANSCRIPTION REGULATOR Compound LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 Source Homo sapiens (Human) (H31_HUMAN) Sequence A:  GVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLF IRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRV HSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLA AARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAM VVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPK EKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQAL EVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLK EKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCK EYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWH FANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYS CVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQ TFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQ RMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELF LFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILK GIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGND YDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVH GALLSGLREAGRIADQFLGAMYTL Description (1)  LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 (E.C.1.-.-.-), REST COREPRESSOR 1, HISTONE H3.1 Functional site 1) chain A residue 754 type sequence D description BINDING SITE FOR RESIDUE CL A1839 source : AC1 2) chain A residue 285 type sequence G description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 3) chain A residue 287 type sequence G description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 4) chain A residue 288 type sequence V description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 5) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 6) chain A residue 307 type sequence L description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 7) chain A residue 308 type sequence E description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 8) chain A residue 309 type sequence A description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 9) chain A residue 310 type sequence R description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 10) chain A residue 314 type sequence G description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 11) chain A residue 315 type sequence G description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 12) chain A residue 316 type sequence R description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 13) chain A residue 317 type sequence V description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 14) chain A residue 329 type sequence L description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 15) chain A residue 330 type sequence G description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 16) chain A residue 331 type sequence A description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 17) chain A residue 332 type sequence M description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 18) chain A residue 333 type sequence V description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 19) chain A residue 588 type sequence T description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 20) chain A residue 590 type sequence V description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 21) chain A residue 624 type sequence T description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 22) chain A residue 625 type sequence L description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 23) chain A residue 626 type sequence P description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 24) chain A residue 751 type sequence W description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 25) chain A residue 756 type sequence W description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 26) chain A residue 760 type sequence S description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 27) chain A residue 761 type sequence Y description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 28) chain A residue 800 type sequence G description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 29) chain A residue 801 type sequence E description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 30) chain A residue 809 type sequence A description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 31) chain A residue 810 type sequence T description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 32) chain A residue 811 type sequence V description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 33) chain A residue 814 type sequence A description BINDING SITE FOR RESIDUE FDA A 900 source : AC2 34) chain A residue 526 type sequence R description BINDING SITE FOR RESIDUE GOL A1837 source : AC3 35) chain A residue 688 type sequence R description BINDING SITE FOR RESIDUE GOL A1837 source : AC3 36) chain A residue 469 type MOD_RES sequence K description N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 503 type MOD_RES sequence K description 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 source Swiss-Prot : SWS_FT_FI4 38) chain A residue 308 type MOD_RES sequence E description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 310 type MOD_RES sequence R description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 316 type MOD_RES sequence R description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 332 type MOD_RES sequence M description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 801 type MOD_RES sequence E description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 810 type MOD_RES sequence T description Citrulline; alternate => ECO:0000269|PubMed:16567635 source Swiss-Prot : SWS_FT_FI1

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