eF-site ID 2uwp-A PDB Code 2uwp Chain A click to enlarge Title Factor Xa inhibitor complex Classification HYDROLASE Compound COAGULATION FACTOR X Source ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; Sequence A:  IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTA AHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRF TKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLM TQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSS SFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTR Description Functional site 1) chain A residue 70 type sequence D description BINDING SITE FOR RESIDUE CA A1246 source : AC1 2) chain A residue 72 type sequence N description BINDING SITE FOR RESIDUE CA A1246 source : AC1 3) chain A residue 75 type sequence Q description BINDING SITE FOR RESIDUE CA A1246 source : AC1 4) chain A residue 77 type sequence E description BINDING SITE FOR RESIDUE CA A1246 source : AC1 5) chain A residue 80 type sequence E description BINDING SITE FOR RESIDUE CA A1246 source : AC1 6) chain A residue 185 type sequence Y description BINDING SITE FOR RESIDUE MG A1247 source : AC2 7) chain A residue 185 type sequence Y description BINDING SITE FOR RESIDUE MG A1247 source : AC2 8) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE MG A1247 source : AC2 9) chain A residue 224 type sequence K description BINDING SITE FOR RESIDUE MG A1247 source : AC2 10) chain A residue 96 type sequence K description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 11) chain A residue 97 type sequence E description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 12) chain A residue 98 type sequence T description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 13) chain A residue 99 type sequence Y description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 14) chain A residue 174 type sequence F description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 15) chain A residue 189 type sequence D description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 16) chain A residue 190 type sequence A description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 17) chain A residue 192 type sequence Q description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 18) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 19) chain A residue 215 type sequence W description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 20) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 21) chain A residue 219 type sequence G description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 22) chain A residue 226 type sequence G description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 23) chain A residue 227 type sequence I description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 24) chain A residue 228 type sequence Y description BINDING SITE FOR RESIDUE 894 A1245 source : AC3 25) chain A residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 26) chain A residue 189-200 type prosite sequence DACQGDSGGPHV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPHV source prosite : PS00135

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