eF-site ID 2uwd-A PDB Code 2uwd Chain A click to enlarge Title Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs Classification CHAPERONE Compound HEAT SHOCK PROTEIN HSP 90-ALPHA Source Homo sapiens (Human) (HS90A_HUMAN) Sequence A:  EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDA LDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTG IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFG VGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTD TGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIG YPITLFVEK Description Functional site 1) chain A residue 86 type sequence D description BINDING SITE FOR RESIDUE MG A1225 source : AC1 2) chain A residue 87 type sequence R description BINDING SITE FOR RESIDUE MG A1225 source : AC1 3) chain A residue 189 type sequence H description BINDING SITE FOR RESIDUE MG A1225 source : AC1 4) chain A residue 60 type sequence R description BINDING SITE FOR RESIDUE MG A1226 source : AC2 5) chain A residue 110 type sequence I description BINDING SITE FOR RESIDUE MG A1226 source : AC2 6) chain A residue 113 type sequence S description BINDING SITE FOR RESIDUE MG A1226 source : AC2 7) chain A residue 54 type sequence D description BINDING SITE FOR RESIDUE SO4 A1227 source : AC3 8) chain A residue 48 type sequence L description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 9) chain A residue 51 type sequence N description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 10) chain A residue 52 type sequence S description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 11) chain A residue 55 type sequence A description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 12) chain A residue 58 type sequence K description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 13) chain A residue 93 type sequence D description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 14) chain A residue 96 type sequence I description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 15) chain A residue 97 type sequence G description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 16) chain A residue 98 type sequence M description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 17) chain A residue 102 type sequence D description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 18) chain A residue 107 type sequence L description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 19) chain A residue 108 type sequence G description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 20) chain A residue 138 type sequence F description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 21) chain A residue 184 type sequence T description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 22) chain A residue 186 type sequence V description BINDING SITE FOR RESIDUE 2GG A1228 source : AC4 23) chain A residue 38-47 type prosite sequence YSNKEIFLRE description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE source prosite : PS00298 24) chain A residue 52 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 25) chain A residue 94 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI1 26) chain A residue 139 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 27) chain A residue 113 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 59 type MOD_RES sequence I description N6-acetyllysine => ECO:0000250|UniProtKB:P07901 source Swiss-Prot : SWS_FT_FI4 29) chain A residue 85 type MOD_RES sequence Q description N6-acetyllysine => ECO:0000250|UniProtKB:P07901 source Swiss-Prot : SWS_FT_FI4

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