eF-site ID 2uw2-A PDB Code 2uw2 Chain A click to enlarge Title Crystal structure of human ribonucleotide reductase subunit R2 Classification OXIDOREDUCTASE Compound RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M2 SUBUNIT Source Homo sapiens (Human) (RIR2_HUMAN) Sequence A:  GVEDEPLLRENPIFPIEYHDIWQMYKKAEASFWTAEEVDL SKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERF SQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKE REFLMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIF FSGSFASIFWLKKRGPMPGLTFSNELISRDEGLHCDFACL MFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGM NCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFM Description (1)  RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M2 SUBUNIT (E.C.1.17.4.1) Functional site 1) chain A residue 169 type sequence E description BINDING SITE FOR RESIDUE FE A1351 source : AC1 2) chain A residue 232 type sequence E description BINDING SITE FOR RESIDUE FE A1351 source : AC1 3) chain A residue 266 type sequence E description BINDING SITE FOR RESIDUE FE A1351 source : AC1 4) chain A residue 269 type sequence H description BINDING SITE FOR RESIDUE FE A1351 source : AC1 5) chain A residue 138 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU10014 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 172 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU10014 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 169 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 8) chain A residue 232 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 9) chain A residue 266 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 10) chain A residue 269 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 11) chain A residue 176 type ACT_SITE sequence Y description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10014 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 168-184 type prosite sequence MENIHSEMYSLLIDTYI description RIBORED_SMALL Ribonucleotide reductase small subunit signature. MEn.IHSeMYslLidtYI source prosite : PS00368

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