eF-site ID 2uue-D PDB Code 2uue Chain D click to enlarge Title REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors Classification TRANSFERASE/INHIBITOR Compound CELL DIVISION PROTEIN KINASE 2 Source (2UUE) Sequence D:  VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAIL VDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAM FLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK NSKYHGVSLLNPPETLNL Description Functional site 1) chain D residue 217 type sequence W description BINDING SITE FOR RESIDUE GVC F 1433 source : AC4 2) chain D residue 220 type sequence E description BINDING SITE FOR RESIDUE GVC F 1433 source : AC4 3) chain D residue 221 type sequence V description BINDING SITE FOR RESIDUE GVC F 1433 source : AC4 4) chain D residue 254 type sequence Q description BINDING SITE FOR RESIDUE GVC F 1433 source : AC4 5) chain D residue 281 type sequence I description BINDING SITE FOR RESIDUE GVC F 1433 source : AC4 6) chain D residue 282 type sequence T description BINDING SITE FOR RESIDUE GVC F 1433 source : AC4 7) chain D residue 283 type sequence D description BINDING SITE FOR RESIDUE GVC F 1433 source : AC4

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