eF-site ID 2src-A PDB Code 2src Chain A click to enlarge Title CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP Classification TYROSINE-PROTEIN KINASE Compound TYROSINE-PROTEIN KINASE SRC Source Homo sapiens (Human) (SRC_HUMAN) Sequence A:  TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHS LSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLL NAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT VCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWM GTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVA DFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC PPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST EPQXQPGENL Description Functional site 1) chain A residue 273 type sequence L description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 2) chain A residue 276 type sequence G description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 3) chain A residue 281 type sequence V description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 4) chain A residue 293 type sequence A description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 5) chain A residue 295 type sequence K description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 6) chain A residue 338 type sequence T description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 7) chain A residue 339 type sequence E description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 8) chain A residue 340 type sequence Y description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 9) chain A residue 341 type sequence M description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 10) chain A residue 345 type sequence S description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 11) chain A residue 386 type sequence D description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 12) chain A residue 388 type sequence R description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 13) chain A residue 391 type sequence N description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 14) chain A residue 393 type sequence L description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 15) chain A residue 404 type sequence D description BINDING SITE FOR RESIDUE ANP A 1 source : AC1 16) chain A residue 273-295 type prosite sequence LGQGCFGEVWMGTWNGTTRVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK source prosite : PS00107 17) chain A residue 382-394 type prosite sequence YVHRDLRAANILV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV source prosite : PS00109 18) chain A residue 387 type ACT_SITE sequence L description Proton acceptor source Swiss-Prot : SWS_FT_FI1 19) chain A residue 274 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 20) chain A residue 296 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 21) chain A residue 185 type MOD_RES sequence C description Phosphotyrosine => ECO:0000250|UniProtKB:P05480 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 417 type MOD_RES sequence T description Phosphotyrosine; by FAK2 => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 528 type MOD_RES sequence Q description Phosphotyrosine; by CSK => ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:26936507, ECO:0000269|PubMed:7525268, ECO:0000269|PubMed:7929427, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5

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