|
eF-site ID
|
2roc_7-AB |
PDB Code
|
2roc |
Model
|
7 |
Chain
|
A, B |
|
click to enlarge
|
|
Title
|
Solution structure of Mcl-1 Complexed with Puma |
Classification
|
APOPTOSIS |
Compound
|
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
Source
|
Mus musculus (Mouse) (BBC3_MOUSE) |
|
Sequence
|
A: |
GPLGSEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAA
GRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKS
FSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQES
FIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLE
GG
|
B: |
EEEWAREIGAQLRRIADDLNAQYERRM
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
234-253 |
type |
prosite |
sequence |
VFKDGVTNWGRIVTLISFGA
|
description |
BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFkDGvtNWGRIVTLIsFGA
|
source |
prosite : PS01080
|
|
2)
|
chain |
A |
residue |
286-297 |
type |
prosite |
sequence |
WLVKQRGWDGFV
|
description |
BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV
|
source |
prosite : PS01258
|
|
3)
|
chain |
A |
residue |
190-204 |
type |
prosite |
sequence |
ALETLRRVGDGVQRN
|
description |
BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN
|
source |
prosite : PS01259
|
|
4)
|
chain |
A |
residue |
175 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q07820
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
5)
|
chain |
A |
residue |
178 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q07820
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|