eF-site ID 2roc_16-A
PDB Code 2roc
Model 16
Chain A

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Title Solution structure of Mcl-1 Complexed with Puma
Classification APOPTOSIS
Compound Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Source Mus musculus (Mouse) (BBC3_MOUSE)
Sequence A:  GPLGSEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAA
GRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKS
FSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQES
FIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLE
GG
Description


Functional site

1) chain A
residue 175
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q07820
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 178
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q07820
source Swiss-Prot : SWS_FT_FI1

3) chain A
residue 234-253
type prosite
sequence VFKDGVTNWGRIVTLISFGA
description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFkDGvtNWGRIVTLIsFGA
source prosite : PS01080

4) chain A
residue 286-297
type prosite
sequence WLVKQRGWDGFV
description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV
source prosite : PS01258

5) chain A
residue 190-204
type prosite
sequence ALETLRRVGDGVQRN
description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN
source prosite : PS01259


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