eF-site ID 2rnw_3-AB
PDB Code 2rnw
Model 3
Chain A, B

click to enlarge
Title The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the Human Transcriptional Co-Activators PCAf and CBP
Classification TRANSFERASE/NUCLEAR PROTEIN
Compound Histone acetyltransferase PCAF
Source Homo sapiens (Human) (H3_YEAST)
Sequence A:  GSHMSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKR
TEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQR
VFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
B:  ARTKQTARXSTGGKA
Description


Functional site

1) chain B
residue 14
type MOD_RES
sequence K
description N6-butyryllysine; alternate => ECO:0000269|PubMed:19113941, ECO:0000269|PubMed:27105113
source Swiss-Prot : SWS_FT_FI4

2) chain B
residue 4
type MOD_RES
sequence K
description N6-methyllysine; alternate => ECO:0000269|PubMed:11742990, ECO:0000269|PubMed:11751634, ECO:0000269|PubMed:11752412, ECO:0000269|PubMed:12152067, ECO:0000269|PubMed:12353038, ECO:0000269|PubMed:12845608, ECO:0000269|PubMed:15949446, ECO:0000269|PubMed:16122352, ECO:0000269|PubMed:16168379, ECO:0000269|PubMed:16185711, ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI1

3) chain B
residue 10
type MOD_RES
sequence S
description Phosphoserine => ECO:0000269|PubMed:10911986, ECO:0000269|PubMed:10975519, ECO:0000269|PubMed:15719021
source Swiss-Prot : SWS_FT_FI3

4) chain A
residue 745-802
type prosite
sequence AWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVS
KKLFMADLQRVFTNCKEY
description BROMODOMAIN_1 Bromodomain signature. AwpFmepvKrteap..GYYevIrfpMdlktMserlknry..Yvskklfmadlqr.VftNCkeY
source prosite : PS00633

5) chain B
residue 9
type MOD_RES
sequence X
description N6-methyllysine; alternate => ECO:0000269|PubMed:17194708
source Swiss-Prot : SWS_FT_FI2


Display surface

Download
Links