|
eF-site ID
|
2rnw_16-AB |
PDB Code
|
2rnw |
Model
|
16 |
Chain
|
A, B |
|
click to enlarge
|
|
Title
|
The Structural Basis for Site-Specific Lysine-Acetylated Histone Recognition by the Bromodomains of the Human Transcriptional Co-Activators PCAf and CBP |
Classification
|
TRANSFERASE/NUCLEAR PROTEIN |
Compound
|
Histone acetyltransferase PCAF |
Source
|
Homo sapiens (Human) (H3_YEAST) |
|
Sequence
|
A: |
GSHMSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKR
TEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQR
VFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
|
B: |
ARTKQTARXSTGGKA
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
745-802 |
type |
prosite |
sequence |
AWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVS
KKLFMADLQRVFTNCKEY
|
description |
BROMODOMAIN_1 Bromodomain signature. AwpFmepvKrteap..GYYevIrfpMdlktMserlknry..Yvskklfmadlqr.VftNCkeY
|
source |
prosite : PS00633
|
|
2)
|
chain |
B |
residue |
4 |
type |
MOD_RES |
sequence |
K
|
description |
N6-methyllysine; alternate => ECO:0000269|PubMed:11742990, ECO:0000269|PubMed:11751634, ECO:0000269|PubMed:11752412, ECO:0000269|PubMed:12152067, ECO:0000269|PubMed:12353038, ECO:0000269|PubMed:12845608, ECO:0000269|PubMed:15949446, ECO:0000269|PubMed:16122352, ECO:0000269|PubMed:16168379, ECO:0000269|PubMed:16185711, ECO:0000269|PubMed:17194708
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
B |
residue |
9 |
type |
MOD_RES |
sequence |
X
|
description |
N6-methyllysine; alternate => ECO:0000269|PubMed:17194708
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
B |
residue |
10 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine => ECO:0000269|PubMed:10911986, ECO:0000269|PubMed:10975519, ECO:0000269|PubMed:15719021
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
5)
|
chain |
B |
residue |
14 |
type |
MOD_RES |
sequence |
K
|
description |
N6-butyryllysine; alternate => ECO:0000269|PubMed:19113941, ECO:0000269|PubMed:27105113
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|