|
|
eF-site ID
|
2rjq-A |
|
PDB Code
|
2rjq |
|
Chain
|
A |
|
click to enlarge
|
|
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Title
|
Crystal structure of ADAMTS5 with inhibitor bound |
|
Classification
|
HYDROLASE |
|
Compound
|
ADAMTS-5 |
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Source
|
(ATS5_HUMAN) |
|
|
Sequence
|
A: |
SRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYS
HASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCK
WQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMAD
VGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDS
KFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF
LDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGP
EYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCG
KGRICLQGKCVD
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
411 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
410 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:18042673
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
414 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:18042673
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
420 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:18042673
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
498 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18042673
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
A |
| residue |
407-416 |
| type |
prosite |
| sequence |
TVAHEIGHLL
|
| description |
ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHEIGHLL
|
| source |
prosite : PS00142
|
|
|
|