eF-site ID 2rjp-C PDB Code 2rjp Chain C click to enlarge Title Crystal structure of ADAMTS4 with inhibitor bound Classification HYDROLASE Compound ADAMTS-4 Source Homo sapiens (Human) (ATS4_HUMAN) Sequence C:  SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFK HPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRG LNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTV CDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKPCI SLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDN GYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSR HCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPA QACMGGRCLH Description Functional site 1) chain C residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN C 1 source : AC9 2) chain C residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN C 1 source : AC9 3) chain C residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN C 1 source : AC9 4) chain C residue 320 type sequence D description BINDING SITE FOR RESIDUE CA C 2 source : BC1 5) chain C residue 321 type sequence L description BINDING SITE FOR RESIDUE CA C 2 source : BC1 6) chain C residue 327 type sequence C description BINDING SITE FOR RESIDUE CA C 2 source : BC1 7) chain C residue 329 type sequence T description BINDING SITE FOR RESIDUE CA C 2 source : BC1 8) chain C residue 349 type sequence E description BINDING SITE FOR RESIDUE CA C 2 source : BC1 9) chain C residue 221 type sequence E description BINDING SITE FOR RESIDUE CA C 3 source : BC2 10) chain C residue 304 type sequence D description BINDING SITE FOR RESIDUE CA C 3 source : BC2 11) chain C residue 311 type sequence D description BINDING SITE FOR RESIDUE CA C 3 source : BC2 12) chain C residue 423 type sequence C description BINDING SITE FOR RESIDUE CA C 3 source : BC2 13) chain C residue 426 type sequence D description BINDING SITE FOR RESIDUE CA C 3 source : BC2 14) chain C residue 221 type sequence E description BINDING SITE FOR RESIDUE CA C 4 source : BC3 15) chain C residue 304 type sequence D description BINDING SITE FOR RESIDUE CA C 4 source : BC3 16) chain C residue 426 type sequence D description BINDING SITE FOR RESIDUE CA C 4 source : BC3 17) chain C residue 252 type sequence A description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 18) chain C residue 329 type sequence T description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 19) chain C residue 330 type sequence L description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 20) chain C residue 331 type sequence G description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 21) chain C residue 332 type sequence M description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 22) chain C residue 357 type sequence F description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 23) chain C residue 361 type sequence H description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 24) chain C residue 362 type sequence Q description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 25) chain C residue 365 type sequence H description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 26) chain C residue 371 type sequence H description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 27) chain C residue 390 type sequence V description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 28) chain C residue 392 type sequence A description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 29) chain C residue 393 type sequence P description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 30) chain C residue 395 type sequence M description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 31) chain C residue 398 type sequence V description BINDING SITE FOR RESIDUE 886 C 510 source : CC1 32) chain C residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 33) chain C residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 34) chain C residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 35) chain C residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links