eF-site ID 2rjp-B PDB Code 2rjp Chain B click to enlarge Title Crystal structure of ADAMTS4 with inhibitor bound Classification HYDROLASE Compound ADAMTS-4 Source Homo sapiens (Human) (ATS4_HUMAN) Sequence B:  ASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAF KHPSIRNPVSLVVTRLVILGSGPQVGPSAAQTLRSFCAWQ RGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVG TVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKP CISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFL DNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPD SRHCPPCAALWCSGHAMCQTKHSPWADGTPCGPAQACMGG RCLH Description Functional site 1) chain B residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC5 2) chain B residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC5 3) chain B residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN B 1 source : AC5 4) chain B residue 320 type sequence D description BINDING SITE FOR RESIDUE CA B 2 source : AC6 5) chain B residue 321 type sequence L description BINDING SITE FOR RESIDUE CA B 2 source : AC6 6) chain B residue 327 type sequence C description BINDING SITE FOR RESIDUE CA B 2 source : AC6 7) chain B residue 329 type sequence T description BINDING SITE FOR RESIDUE CA B 2 source : AC6 8) chain B residue 349 type sequence E description BINDING SITE FOR RESIDUE CA B 2 source : AC6 9) chain B residue 221 type sequence E description BINDING SITE FOR RESIDUE CA B 3 source : AC7 10) chain B residue 304 type sequence D description BINDING SITE FOR RESIDUE CA B 3 source : AC7 11) chain B residue 311 type sequence D description BINDING SITE FOR RESIDUE CA B 3 source : AC7 12) chain B residue 423 type sequence C description BINDING SITE FOR RESIDUE CA B 3 source : AC7 13) chain B residue 426 type sequence D description BINDING SITE FOR RESIDUE CA B 3 source : AC7 14) chain B residue 221 type sequence E description BINDING SITE FOR RESIDUE CA B 4 source : AC8 15) chain B residue 304 type sequence D description BINDING SITE FOR RESIDUE CA B 4 source : AC8 16) chain B residue 426 type sequence D description BINDING SITE FOR RESIDUE CA B 4 source : AC8 17) chain B residue 252 type sequence A description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 18) chain B residue 329 type sequence T description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 19) chain B residue 330 type sequence L description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 20) chain B residue 331 type sequence G description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 21) chain B residue 357 type sequence F description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 22) chain B residue 361 type sequence H description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 23) chain B residue 362 type sequence Q description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 24) chain B residue 365 type sequence H description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 25) chain B residue 371 type sequence H description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 26) chain B residue 390 type sequence V description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 27) chain B residue 392 type sequence A description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 28) chain B residue 393 type sequence P description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 29) chain B residue 394 type sequence V description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 30) chain B residue 398 type sequence V description BINDING SITE FOR RESIDUE 886 B 510 source : BC8 31) chain B residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1

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