eF-site ID 2rjp-ABCD
PDB Code 2rjp
Chain A, B, C, D

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Title Crystal structure of ADAMTS4 with inhibitor bound
Classification HYDROLASE
Compound ADAMTS-4
Source Homo sapiens (Human) (ATS4_HUMAN)
Sequence A:  ASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAF
KHPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQR
GLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGT
VCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKPC
ISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLD
NGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDS
RHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGP
AQACMGGRCLH
B:  ASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAF
KHPSIRNPVSLVVTRLVILGSGPQVGPSAAQTLRSFCAWQ
RGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVG
TVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKP
CISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFL
DNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPD
SRHCPPCAALWCSGHAMCQTKHSPWADGTPCGPAQACMGG
RCLH
C:  SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFK
HPSIRNPVSLVVTRLVILEGPQVGPSAAQTLRSFCAWQRG
LNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTV
CDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKPCI
SLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDN
GYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSR
HCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPA
QACMGGRCLH
D:  SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFK
HPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGL
NTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVC
DPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKPCIS
LNSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCL
LDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPPCA
ALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC
Description


Functional site

1) chain A
residue 361
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 1
source : AC1

2) chain A
residue 365
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 1
source : AC1

3) chain A
residue 371
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 1
source : AC1

4) chain A
residue 320
type
sequence D
description BINDING SITE FOR RESIDUE CA A 2
source : AC2

5) chain A
residue 321
type
sequence L
description BINDING SITE FOR RESIDUE CA A 2
source : AC2

6) chain A
residue 327
type
sequence C
description BINDING SITE FOR RESIDUE CA A 2
source : AC2

7) chain A
residue 329
type
sequence T
description BINDING SITE FOR RESIDUE CA A 2
source : AC2

8) chain A
residue 349
type
sequence E
description BINDING SITE FOR RESIDUE CA A 2
source : AC2

9) chain A
residue 221
type
sequence E
description BINDING SITE FOR RESIDUE CA A 3
source : AC3

10) chain A
residue 304
type
sequence D
description BINDING SITE FOR RESIDUE CA A 3
source : AC3

11) chain A
residue 311
type
sequence D
description BINDING SITE FOR RESIDUE CA A 3
source : AC3

12) chain A
residue 423
type
sequence C
description BINDING SITE FOR RESIDUE CA A 3
source : AC3

13) chain A
residue 426
type
sequence D
description BINDING SITE FOR RESIDUE CA A 3
source : AC3

14) chain A
residue 221
type
sequence E
description BINDING SITE FOR RESIDUE CA A 4
source : AC4

15) chain A
residue 304
type
sequence D
description BINDING SITE FOR RESIDUE CA A 4
source : AC4

16) chain A
residue 426
type
sequence D
description BINDING SITE FOR RESIDUE CA A 4
source : AC4

17) chain B
residue 361
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 1
source : AC5

18) chain B
residue 365
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 1
source : AC5

19) chain B
residue 371
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 1
source : AC5

20) chain B
residue 320
type
sequence D
description BINDING SITE FOR RESIDUE CA B 2
source : AC6

21) chain B
residue 321
type
sequence L
description BINDING SITE FOR RESIDUE CA B 2
source : AC6

22) chain B
residue 327
type
sequence C
description BINDING SITE FOR RESIDUE CA B 2
source : AC6

23) chain B
residue 329
type
sequence T
description BINDING SITE FOR RESIDUE CA B 2
source : AC6

24) chain B
residue 349
type
sequence E
description BINDING SITE FOR RESIDUE CA B 2
source : AC6

25) chain B
residue 221
type
sequence E
description BINDING SITE FOR RESIDUE CA B 3
source : AC7

26) chain B
residue 304
type
sequence D
description BINDING SITE FOR RESIDUE CA B 3
source : AC7

27) chain B
residue 311
type
sequence D
description BINDING SITE FOR RESIDUE CA B 3
source : AC7

28) chain B
residue 423
type
sequence C
description BINDING SITE FOR RESIDUE CA B 3
source : AC7

29) chain B
residue 426
type
sequence D
description BINDING SITE FOR RESIDUE CA B 3
source : AC7

30) chain B
residue 221
type
sequence E
description BINDING SITE FOR RESIDUE CA B 4
source : AC8

31) chain B
residue 304
type
sequence D
description BINDING SITE FOR RESIDUE CA B 4
source : AC8

32) chain B
residue 426
type
sequence D
description BINDING SITE FOR RESIDUE CA B 4
source : AC8

33) chain C
residue 361
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 1
source : AC9

34) chain C
residue 365
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 1
source : AC9

35) chain C
residue 371
type
sequence H
description BINDING SITE FOR RESIDUE ZN C 1
source : AC9

36) chain C
residue 320
type
sequence D
description BINDING SITE FOR RESIDUE CA C 2
source : BC1

37) chain C
residue 321
type
sequence L
description BINDING SITE FOR RESIDUE CA C 2
source : BC1

38) chain C
residue 327
type
sequence C
description BINDING SITE FOR RESIDUE CA C 2
source : BC1

39) chain C
residue 329
type
sequence T
description BINDING SITE FOR RESIDUE CA C 2
source : BC1

40) chain C
residue 349
type
sequence E
description BINDING SITE FOR RESIDUE CA C 2
source : BC1

41) chain C
residue 221
type
sequence E
description BINDING SITE FOR RESIDUE CA C 3
source : BC2

42) chain C
residue 304
type
sequence D
description BINDING SITE FOR RESIDUE CA C 3
source : BC2

43) chain C
residue 311
type
sequence D
description BINDING SITE FOR RESIDUE CA C 3
source : BC2

44) chain C
residue 423
type
sequence C
description BINDING SITE FOR RESIDUE CA C 3
source : BC2

45) chain C
residue 426
type
sequence D
description BINDING SITE FOR RESIDUE CA C 3
source : BC2

46) chain C
residue 221
type
sequence E
description BINDING SITE FOR RESIDUE CA C 4
source : BC3

47) chain C
residue 304
type
sequence D
description BINDING SITE FOR RESIDUE CA C 4
source : BC3

48) chain C
residue 426
type
sequence D
description BINDING SITE FOR RESIDUE CA C 4
source : BC3

49) chain D
residue 361
type
sequence H
description BINDING SITE FOR RESIDUE ZN D 1
source : BC4

50) chain D
residue 365
type
sequence H
description BINDING SITE FOR RESIDUE ZN D 1
source : BC4

51) chain D
residue 371
type
sequence H
description BINDING SITE FOR RESIDUE ZN D 1
source : BC4

52) chain D
residue 320
type
sequence D
description BINDING SITE FOR RESIDUE CA D 2
source : BC5

53) chain D
residue 321
type
sequence L
description BINDING SITE FOR RESIDUE CA D 2
source : BC5

54) chain D
residue 327
type
sequence C
description BINDING SITE FOR RESIDUE CA D 2
source : BC5

55) chain D
residue 329
type
sequence T
description BINDING SITE FOR RESIDUE CA D 2
source : BC5

56) chain D
residue 349
type
sequence E
description BINDING SITE FOR RESIDUE CA D 2
source : BC5

57) chain D
residue 221
type
sequence E
description BINDING SITE FOR RESIDUE CA D 3
source : BC6

58) chain D
residue 304
type
sequence D
description BINDING SITE FOR RESIDUE CA D 3
source : BC6

59) chain D
residue 311
type
sequence D
description BINDING SITE FOR RESIDUE CA D 3
source : BC6

60) chain D
residue 423
type
sequence C
description BINDING SITE FOR RESIDUE CA D 3
source : BC6

61) chain D
residue 426
type
sequence D
description BINDING SITE FOR RESIDUE CA D 3
source : BC6

62) chain D
residue 221
type
sequence E
description BINDING SITE FOR RESIDUE CA D 4
source : BC7

63) chain D
residue 304
type
sequence D
description BINDING SITE FOR RESIDUE CA D 4
source : BC7

64) chain D
residue 426
type
sequence D
description BINDING SITE FOR RESIDUE CA D 4
source : BC7

65) chain B
residue 252
type
sequence A
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

66) chain B
residue 329
type
sequence T
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

67) chain B
residue 330
type
sequence L
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

68) chain B
residue 331
type
sequence G
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

69) chain B
residue 357
type
sequence F
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

70) chain B
residue 361
type
sequence H
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

71) chain B
residue 362
type
sequence Q
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

72) chain B
residue 365
type
sequence H
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

73) chain B
residue 371
type
sequence H
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

74) chain B
residue 390
type
sequence V
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

75) chain B
residue 392
type
sequence A
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

76) chain B
residue 393
type
sequence P
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

77) chain B
residue 394
type
sequence V
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

78) chain B
residue 398
type
sequence V
description BINDING SITE FOR RESIDUE 886 B 510
source : BC8

79) chain D
residue 329
type
sequence T
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

80) chain D
residue 330
type
sequence L
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

81) chain D
residue 331
type
sequence G
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

82) chain D
residue 332
type
sequence M
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

83) chain D
residue 357
type
sequence F
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

84) chain D
residue 361
type
sequence H
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

85) chain D
residue 362
type
sequence Q
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

86) chain D
residue 365
type
sequence H
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

87) chain D
residue 371
type
sequence H
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

88) chain D
residue 390
type
sequence V
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

89) chain D
residue 392
type
sequence A
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

90) chain D
residue 393
type
sequence P
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

91) chain D
residue 394
type
sequence V
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

92) chain D
residue 395
type
sequence M
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

93) chain D
residue 398
type
sequence V
description BINDING SITE FOR RESIDUE 886 D 510
source : BC9

94) chain C
residue 252
type
sequence A
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

95) chain C
residue 329
type
sequence T
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

96) chain C
residue 330
type
sequence L
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

97) chain C
residue 331
type
sequence G
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

98) chain C
residue 332
type
sequence M
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

99) chain C
residue 357
type
sequence F
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

100) chain C
residue 361
type
sequence H
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

101) chain C
residue 362
type
sequence Q
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

102) chain C
residue 365
type
sequence H
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

103) chain C
residue 371
type
sequence H
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

104) chain C
residue 390
type
sequence V
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

105) chain C
residue 392
type
sequence A
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

106) chain C
residue 393
type
sequence P
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

107) chain C
residue 395
type
sequence M
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

108) chain C
residue 398
type
sequence V
description BINDING SITE FOR RESIDUE 886 C 510
source : CC1

109) chain A
residue 252
type
sequence A
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

110) chain A
residue 329
type
sequence T
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

111) chain A
residue 330
type
sequence L
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

112) chain A
residue 331
type
sequence G
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

113) chain A
residue 332
type
sequence M
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

114) chain A
residue 357
type
sequence F
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

115) chain A
residue 361
type
sequence H
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

116) chain A
residue 362
type
sequence Q
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

117) chain A
residue 365
type
sequence H
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

118) chain A
residue 371
type
sequence H
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

119) chain A
residue 390
type
sequence V
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

120) chain A
residue 392
type
sequence A
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

121) chain A
residue 393
type
sequence P
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

122) chain A
residue 394
type
sequence V
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

123) chain A
residue 398
type
sequence V
description BINDING SITE FOR RESIDUE 886 A 510
source : CC2

124) chain A
residue 361
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

125) chain D
residue 361
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

126) chain D
residue 365
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

127) chain D
residue 371
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

128) chain A
residue 365
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

129) chain A
residue 371
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

130) chain B
residue 361
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

131) chain B
residue 365
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

132) chain B
residue 371
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

133) chain C
residue 361
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

134) chain C
residue 365
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

135) chain C
residue 371
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI2

136) chain A
residue 362
type ACT_SITE
sequence Q
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI1

137) chain B
residue 362
type ACT_SITE
sequence Q
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI1

138) chain C
residue 362
type ACT_SITE
sequence Q
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI1

139) chain D
residue 362
type ACT_SITE
sequence Q
description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673
source Swiss-Prot : SWS_FT_FI1


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