eF-site ID 2rjp-D PDB Code 2rjp Chain D click to enlarge Title Crystal structure of ADAMTS4 with inhibitor bound Classification HYDROLASE Compound ADAMTS-4 Source Homo sapiens (Human) (ATS4_HUMAN) Sequence D:  SLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFK HPSIRNPVSLVVTRLVILGPQVGPSAAQTLRSFCAWQRGL NTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVC DPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHDNSKPCIS LNSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCL LDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPPCA ALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC Description Functional site 1) chain D residue 361 type sequence H description BINDING SITE FOR RESIDUE ZN D 1 source : BC4 2) chain D residue 365 type sequence H description BINDING SITE FOR RESIDUE ZN D 1 source : BC4 3) chain D residue 371 type sequence H description BINDING SITE FOR RESIDUE ZN D 1 source : BC4 4) chain D residue 320 type sequence D description BINDING SITE FOR RESIDUE CA D 2 source : BC5 5) chain D residue 321 type sequence L description BINDING SITE FOR RESIDUE CA D 2 source : BC5 6) chain D residue 327 type sequence C description BINDING SITE FOR RESIDUE CA D 2 source : BC5 7) chain D residue 329 type sequence T description BINDING SITE FOR RESIDUE CA D 2 source : BC5 8) chain D residue 349 type sequence E description BINDING SITE FOR RESIDUE CA D 2 source : BC5 9) chain D residue 221 type sequence E description BINDING SITE FOR RESIDUE CA D 3 source : BC6 10) chain D residue 304 type sequence D description BINDING SITE FOR RESIDUE CA D 3 source : BC6 11) chain D residue 311 type sequence D description BINDING SITE FOR RESIDUE CA D 3 source : BC6 12) chain D residue 423 type sequence C description BINDING SITE FOR RESIDUE CA D 3 source : BC6 13) chain D residue 426 type sequence D description BINDING SITE FOR RESIDUE CA D 3 source : BC6 14) chain D residue 221 type sequence E description BINDING SITE FOR RESIDUE CA D 4 source : BC7 15) chain D residue 304 type sequence D description BINDING SITE FOR RESIDUE CA D 4 source : BC7 16) chain D residue 426 type sequence D description BINDING SITE FOR RESIDUE CA D 4 source : BC7 17) chain D residue 329 type sequence T description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 18) chain D residue 330 type sequence L description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 19) chain D residue 331 type sequence G description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 20) chain D residue 332 type sequence M description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 21) chain D residue 357 type sequence F description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 22) chain D residue 361 type sequence H description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 23) chain D residue 362 type sequence Q description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 24) chain D residue 365 type sequence H description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 25) chain D residue 371 type sequence H description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 26) chain D residue 390 type sequence V description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 27) chain D residue 392 type sequence A description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 28) chain D residue 393 type sequence P description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 29) chain D residue 394 type sequence V description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 30) chain D residue 395 type sequence M description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 31) chain D residue 398 type sequence V description BINDING SITE FOR RESIDUE 886 D 510 source : BC9 32) chain D residue 361 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 33) chain D residue 365 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 34) chain D residue 371 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI2 35) chain D residue 362 type ACT_SITE sequence Q description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 source Swiss-Prot : SWS_FT_FI1

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