eF-site ID 2rjh-ABCD PDB Code 2rjh Chain A, B, C, D click to enlarge Title Crystal structure of biosynthetic alaine racemase in D-cycloserine-bound form from Escherichia coli Classification ISOMERASE Compound Alanine racemase Source Escherichia coli (strain K12) (ALR1_ECOLI) Sequence A:  MQAATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGH GLLETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEG FFDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVW MXLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHF ARADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLW PQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSS LIAVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPR AAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGD PVILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD B:  MQAATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGH GLLETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEG FFDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVW MXLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHF ARADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLW PQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSS LIAVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPR AAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGD PVILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD C:  AATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGL LETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGFF DARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMX LDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFAR ADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQ SHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLI AVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAA PSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPV ILWGEGLPVEMTKVSAYELITRLTSRVAMKYVD D:  AATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGL LETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGFF DARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMX LDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFAR ADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQ SHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLI AVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAA PSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPV ILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD Description Functional site 1) chain A residue 19 type sequence R description BINDING SITE FOR RESIDUE SO4 A 360 source : AC1 2) chain B residue 266 type sequence R description BINDING SITE FOR RESIDUE SO4 A 360 source : AC1 3) chain A residue 266 type sequence R description BINDING SITE FOR RESIDUE SO4 B 360 source : AC2 4) chain B residue 19 type sequence R description BINDING SITE FOR RESIDUE SO4 B 360 source : AC2 5) chain C residue 19 type sequence R description BINDING SITE FOR RESIDUE SO4 C 360 source : AC3 6) chain D residue 266 type sequence R description BINDING SITE FOR RESIDUE SO4 C 360 source : AC3 7) chain D residue 315 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 360 source : AC3 8) chain A residue 162 type sequence R description BINDING SITE FOR RESIDUE SO4 A 361 source : AC4 9) chain A residue 168 type sequence C description BINDING SITE FOR RESIDUE SO4 A 361 source : AC4 10) chain B residue 162 type sequence R description BINDING SITE FOR RESIDUE SO4 B 361 source : AC5 11) chain B residue 168 type sequence C description BINDING SITE FOR RESIDUE SO4 B 361 source : AC5 12) chain A residue 34 type sequence K description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 13) chain A residue 38 type sequence Y description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 14) chain A residue 129 type sequence R description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 15) chain A residue 159 type sequence H description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 16) chain A residue 193 type sequence A description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 17) chain A residue 194 type sequence S description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 18) chain A residue 209 type sequence R description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 19) chain A residue 211 type sequence G description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 20) chain A residue 212 type sequence I description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 21) chain A residue 343 type sequence Y description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 22) chain B residue 255 type sequence Y description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 23) chain B residue 274 type sequence Y description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 24) chain B residue 302 type sequence A description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 25) chain B residue 303 type sequence M description BINDING SITE FOR RESIDUE DCS A 362 source : AC6 26) chain A residue 255 type sequence Y description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 27) chain A residue 274 type sequence Y description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 28) chain A residue 302 type sequence A description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 29) chain A residue 303 type sequence M description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 30) chain B residue 34 type sequence K description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 31) chain B residue 38 type sequence Y description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 32) chain B residue 129 type sequence R description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 33) chain B residue 159 type sequence H description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 34) chain B residue 193 type sequence A description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 35) chain B residue 194 type sequence S description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 36) chain B residue 209 type sequence R description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 37) chain B residue 211 type sequence G description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 38) chain B residue 212 type sequence I description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 39) chain B residue 343 type sequence Y description BINDING SITE FOR RESIDUE DCS B 362 source : AC7 40) chain C residue 34 type sequence K description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 41) chain C residue 38 type sequence Y description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 42) chain C residue 129 type sequence R description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 43) chain C residue 159 type sequence H description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 44) chain C residue 193 type sequence A description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 45) chain C residue 194 type sequence S description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 46) chain C residue 209 type sequence R description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 47) chain C residue 211 type sequence G description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 48) chain C residue 212 type sequence I description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 49) chain C residue 343 type sequence Y description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 50) chain D residue 255 type sequence Y description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 51) chain D residue 274 type sequence Y description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 52) chain D residue 302 type sequence A description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 53) chain D residue 303 type sequence M description BINDING SITE FOR RESIDUE DCS C 362 source : AC8 54) chain C residue 255 type sequence Y description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 55) chain C residue 274 type sequence Y description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 56) chain C residue 303 type sequence M description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 57) chain D residue 34 type sequence K description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 58) chain D residue 38 type sequence Y description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 59) chain D residue 78 type sequence L description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 60) chain D residue 129 type sequence R description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 61) chain D residue 159 type sequence H description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 62) chain D residue 193 type sequence A description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 63) chain D residue 194 type sequence S description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 64) chain D residue 209 type sequence R description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 65) chain D residue 211 type sequence G description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 66) chain D residue 212 type sequence I description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 67) chain D residue 343 type sequence Y description BINDING SITE FOR RESIDUE DCS D 360 source : AC9 68) chain A residue 129 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 69) chain A residue 303 type BINDING sequence M description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 70) chain B residue 129 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 71) chain B residue 303 type BINDING sequence M description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 72) chain C residue 129 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 73) chain C residue 303 type BINDING sequence M description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 74) chain D residue 129 type BINDING sequence R description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 75) chain D residue 303 type BINDING sequence M description BINDING => ECO:0000305|PubMed:18434499 source Swiss-Prot : SWS_FT_FI3 76) chain A residue 34 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI4 77) chain B residue 34 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI4 78) chain C residue 34 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI4 79) chain D residue 34 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI4 80) chain A residue 122 type MOD_RES sequence X description N6-carboxylysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI5 81) chain B residue 122 type MOD_RES sequence X description N6-carboxylysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI5 82) chain C residue 122 type MOD_RES sequence X description N6-carboxylysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI5 83) chain D residue 122 type MOD_RES sequence X description N6-carboxylysine => ECO:0000269|PubMed:18434499 source Swiss-Prot : SWS_FT_FI5 84) chain A residue 34 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI1 85) chain B residue 34 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI1 86) chain C residue 34 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI1 87) chain D residue 34 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI1 88) chain A residue 255 type ACT_SITE sequence Y description Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI2 89) chain B residue 255 type ACT_SITE sequence Y description Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI2 90) chain C residue 255 type ACT_SITE sequence Y description Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI2 91) chain D residue 255 type ACT_SITE sequence Y description Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI2 92) chain A residue 31-41 type prosite sequence AVVKANAYGHG description ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKANAYGHG source prosite : PS00395

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