eF-site ID 2rio-B PDB Code 2rio Chain B click to enlarge Title Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation of non-conventional splicing Classification HYDROLASE, TRANSFERASE Compound Serine/threonine-protein kinase/endoribonuclease IRE1 Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (IRE1_YEAST) Sequence B:  NFEQSLKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRM LIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIA LELCNLNLQDLVESYNPISLLRQIASGVAHLHSLKIIHRD LKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDS TSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILS KGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATD LISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSD RLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMD RKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGF YDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS Description Functional site 1) chain B residue 145 type sequence N description BINDING SITE FOR RESIDUE MG B 2102 source : AC3 2) chain B residue 171 type sequence D description BINDING SITE FOR RESIDUE MG B 2102 source : AC3 3) chain B residue 171 type sequence D description BINDING SITE FOR RESIDUE SR B 2103 source : AC4 4) chain B residue 24 type sequence G description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 5) chain B residue 25 type sequence Y description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 6) chain B residue 26 type sequence G description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 7) chain B residue 27 type sequence S description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 8) chain B residue 30 type sequence T description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 9) chain B residue 32 type sequence V description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 10) chain B residue 43 type sequence A description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 11) chain B residue 45 type sequence K description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 12) chain B residue 72 type sequence I description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 13) chain B residue 89 type sequence E description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 14) chain B residue 91 type sequence C description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 15) chain B residue 94 type sequence N description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 16) chain B residue 144 type sequence Q description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 17) chain B residue 145 type sequence N description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 18) chain B residue 147 type sequence L description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 19) chain B residue 171 type sequence D description BINDING SITE FOR RESIDUE ADP B 2101 source : AC6 20) chain B residue 23 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 140 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 45 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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