eF-site ID 2rio-A
PDB Code 2rio
Chain A

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Title Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation of non-conventional splicing
Classification HYDROLASE, TRANSFERASE
Compound Serine/threonine-protein kinase/endoribonuclease IRE1
Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (IRE1_YEAST)
Sequence A:  NFEQSLKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRM
LIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIA
LELCNLNLQDLVESKYNPISLLRQIASGVAHLHSLKIIHR
DLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLD
STSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYIL
SKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEAT
DLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVS
DRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFM
DRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDG
FYDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS
Description


Functional site

1) chain A
residue 145
type
sequence N
description BINDING SITE FOR RESIDUE MG A 1102
source : AC1

2) chain A
residue 171
type
sequence D
description BINDING SITE FOR RESIDUE MG A 1102
source : AC1

3) chain A
residue 171
type
sequence D
description BINDING SITE FOR RESIDUE SR A 1103
source : AC2

4) chain A
residue 24
type
sequence G
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

5) chain A
residue 25
type
sequence Y
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

6) chain A
residue 26
type
sequence G
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

7) chain A
residue 27
type
sequence S
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

8) chain A
residue 30
type
sequence T
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

9) chain A
residue 32
type
sequence V
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

10) chain A
residue 43
type
sequence A
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

11) chain A
residue 45
type
sequence K
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

12) chain A
residue 88
type
sequence L
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

13) chain A
residue 89
type
sequence E
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

14) chain A
residue 91
type
sequence C
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

15) chain A
residue 94
type
sequence N
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

16) chain A
residue 144
type
sequence Q
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

17) chain A
residue 145
type
sequence N
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

18) chain A
residue 147
type
sequence L
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

19) chain A
residue 171
type
sequence D
description BINDING SITE FOR RESIDUE ADP A 1101
source : AC5

20) chain A
residue 23
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 136-148
type prosite
sequence IIHRDLKPQNILV
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpqNILV
source prosite : PS00108

22) chain A
residue 140
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 45
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3


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