eF-site ID 2rhw-A PDB Code 2rhw Chain A click to enlarge Title Crystal Structure of the S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, in complex with 3,10-Di-Fluoro HOPDA Classification HYDROLASE Compound 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase Source ORGANISM_SCIENTIFIC: Burkholderia xenovorans; Sequence A:  LTESSTSKFVKINEKGFSDFNIHYNEAGNGETVIMLHGGG PGAGGWSNYYRNVGPFVDAGYRVILKDSPGFNKSDAVVMD EQRGLVNARAVKGLMDALDIDRAHLVGNAMGGATALNFAL EYPDRIGKLILMGPGGLGPSMFAPMPMEGIKLLFKLYAEP SYETLKQMLQVFLYDQSLITEELLQGRWEAIQRQPEHLKN FLISAQKAPLSTWDVTARLGEIKAKTFITWGRDDRFVPLD HGLKLLWNIDDARLHVFSKCGHWAQWEHADEFNRLVIDFL RHA Description Functional site 1) chain A residue 105 type sequence R description BINDING SITE FOR RESIDUE NA A 1 source : AC1 2) chain A residue 35 type sequence T description BINDING SITE FOR RESIDUE MLI A 287 source : AC2 3) chain A residue 65 type sequence R description BINDING SITE FOR RESIDUE MLI A 287 source : AC2 4) chain A residue 102 type sequence D description BINDING SITE FOR RESIDUE MLI A 287 source : AC2 5) chain A residue 103 type sequence I description BINDING SITE FOR RESIDUE MLI A 287 source : AC2 6) chain A residue 104 type sequence D description BINDING SITE FOR RESIDUE MLI A 287 source : AC2 7) chain A residue 105 type sequence R description BINDING SITE FOR RESIDUE MLI A 287 source : AC2 8) chain A residue 180 type sequence S description BINDING SITE FOR RESIDUE MLI A 287 source : AC2 9) chain A residue 182 type sequence I description BINDING SITE FOR RESIDUE MLI A 287 source : AC2 10) chain A residue 41 type sequence G description BINDING SITE FOR RESIDUE MLI A 2 source : AC3 11) chain A residue 42 type sequence G description BINDING SITE FOR RESIDUE MLI A 2 source : AC3 12) chain A residue 43 type sequence G description BINDING SITE FOR RESIDUE MLI A 2 source : AC3 13) chain A residue 111 type sequence N description BINDING SITE FOR RESIDUE MLI A 2 source : AC3 14) chain A residue 112 type sequence A description BINDING SITE FOR RESIDUE MLI A 2 source : AC3 15) chain A residue 113 type sequence M description BINDING SITE FOR RESIDUE MLI A 2 source : AC3 16) chain A residue 156 type sequence L description BINDING SITE FOR RESIDUE MLI A 2 source : AC3 17) chain A residue 265 type sequence H description BINDING SITE FOR RESIDUE MLI A 2 source : AC3 18) chain A residue 41 type sequence G description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 19) chain A residue 42 type sequence G description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 20) chain A residue 43 type sequence G description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 21) chain A residue 51 type sequence N description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 22) chain A residue 111 type sequence N description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 23) chain A residue 112 type sequence A description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 24) chain A residue 113 type sequence M description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 25) chain A residue 138 type sequence G description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 26) chain A residue 139 type sequence G description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 27) chain A residue 153 type sequence I description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 28) chain A residue 156 type sequence L description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 29) chain A residue 175 type sequence F description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 30) chain A residue 190 type sequence R description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 31) chain A residue 213 type sequence L description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 32) chain A residue 239 type sequence F description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 33) chain A residue 240 type sequence V description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 34) chain A residue 265 type sequence H description BINDING SITE FOR RESIDUE C0E A 288 source : AC4 35) chain A residue 265 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI1 36) chain A residue 42 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 37) chain A residue 51 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 38) chain A residue 111 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 39) chain A residue 180 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI2 40) chain A residue 190 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 41) chain A residue 266 type BINDING sequence W description source Swiss-Prot : SWS_FT_FI2 42) chain A residue 112 type SITE sequence A description Transition state stabilizer source Swiss-Prot : SWS_FT_FI3

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