eF-site ID 2rfi-B PDB Code 2rfi Chain B click to enlarge Title Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and dimethylated H3K9 peptide Classification TRANSFERASE Compound Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 Source null (2RFI) Sequence B:  IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTS PMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDG RLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARL QLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVR EEDSYLFDLVYCIDARFYGNVSRFINHHCEPNLVPVRVFM AHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLF SCRCGSPKCRHS Description Functional site 1) chain B residue 1031 type sequence C description BINDING SITE FOR RESIDUE ZN B 501 source : AC5 2) chain B residue 1044 type sequence C description BINDING SITE FOR RESIDUE ZN B 501 source : AC5 3) chain B residue 1074 type sequence C description BINDING SITE FOR RESIDUE ZN B 501 source : AC5 4) chain B residue 1078 type sequence C description BINDING SITE FOR RESIDUE ZN B 501 source : AC5 5) chain B residue 1037 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : AC6 6) chain B residue 1074 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : AC6 7) chain B residue 1080 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : AC6 8) chain B residue 1084 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : AC6 9) chain B residue 1031 type sequence C description BINDING SITE FOR RESIDUE ZN B 503 source : AC7 10) chain B residue 1033 type sequence C description BINDING SITE FOR RESIDUE ZN B 503 source : AC7 11) chain B residue 1037 type sequence C description BINDING SITE FOR RESIDUE ZN B 503 source : AC7 12) chain B residue 1042 type sequence C description BINDING SITE FOR RESIDUE ZN B 503 source : AC7 13) chain B residue 1172 type sequence C description BINDING SITE FOR RESIDUE ZN B 504 source : AC8 14) chain B residue 1225 type sequence C description BINDING SITE FOR RESIDUE ZN B 504 source : AC8 15) chain B residue 1227 type sequence C description BINDING SITE FOR RESIDUE ZN B 504 source : AC8 16) chain B residue 1232 type sequence C description BINDING SITE FOR RESIDUE ZN B 504 source : AC8 17) chain B residue 1105 type sequence M description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 18) chain B residue 1107 type sequence W description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 19) chain B residue 1166 type sequence R description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 20) chain B residue 1169 type sequence N description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 21) chain B residue 1170 type sequence H description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 22) chain B residue 1211 type sequence Y description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 23) chain B residue 1223 type sequence F description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 24) chain B residue 1224 type sequence S description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 25) chain B residue 1225 type sequence C description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 26) chain B residue 1226 type sequence R description BINDING SITE FOR RESIDUE SAH A 102 source : BC1 27) chain B residue 1062 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 28) chain B residue 1064 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 29) chain B residue 1068 type BINDING sequence P description source Swiss-Prot : SWS_FT_FI1 30) chain B residue 1073 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 31) chain B residue 1075 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 32) chain B residue 1105 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI1 33) chain B residue 1109 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI1 34) chain B residue 1111 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 35) chain B residue 1115 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI1 36) chain B residue 1136 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI1 37) chain B residue 1173 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 38) chain B residue 1200 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI1 39) chain B residue 1203 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI1 40) chain B residue 1155 type SITE sequence C description Histone H3K9me binding => ECO:0000269|PubMed:18264113, ECO:0000269|PubMed:20084102 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 1004 type MOD_RES sequence P description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 42) chain B residue 1048 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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