|
|
eF-site ID
|
2rf5-A |
|
PDB Code
|
2rf5 |
|
Chain
|
A |
|
click to enlarge
|
|
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Title
|
Crystal structure of human tankyrase 1- catalytic PARP domain |
|
Classification
|
TRANSFERASE |
|
Compound
|
Tankyrase-1 |
|
Source
|
Homo sapiens (Human) (TNKS1_HUMAN) |
|
|
Sequence
|
A: |
QGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFN
RYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLF
HGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQ
YVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQF
STIKMAHAPPGHHSVIGRPLAYAEYVIYRGEQAYPEYLIT
YQIMKPE
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
1234 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 1
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
1237 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN A 1
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
1242 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 1
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
1245 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 1
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
1184 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE GOL A 1326
|
| source |
: AC2
|
|
|
6)
|
chain |
A |
| residue |
1186 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE GOL A 1326
|
| source |
: AC2
|
|
|
7)
|
chain |
A |
| residue |
1188 |
| type |
|
| sequence |
F
|
| description |
BINDING SITE FOR RESIDUE GOL A 1326
|
| source |
: AC2
|
|
|
8)
|
chain |
A |
| residue |
1192 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE GOL A 1326
|
| source |
: AC2
|
|
|
9)
|
chain |
A |
| residue |
1197 |
| type |
|
| sequence |
F
|
| description |
BINDING SITE FOR RESIDUE GOL A 1326
|
| source |
: AC2
|
|
|
10)
|
chain |
A |
| residue |
1198 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE GOL A 1326
|
| source |
: AC2
|
|
|
11)
|
chain |
A |
| residue |
1201 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE GOL A 1326
|
| source |
: AC2
|
|
|
12)
|
chain |
A |
| residue |
1203 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE GOL A 1326
|
| source |
: AC2
|
|
|
13)
|
chain |
A |
| residue |
1234 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:18436240, ECO:0007744|PDB:2RF5, ECO:0007744|PDB:3UDD, ECO:0007744|PDB:3UH2, ECO:0007744|PDB:3UH4, ECO:0007744|PDB:4DVI, ECO:0007744|PDB:4I9I, ECO:0007744|PDB:4K4E, ECO:0007744|PDB:4K4F, ECO:0007744|PDB:4KRS, ECO:0007744|PDB:4LI6, ECO:0007744|PDB:4LI8, ECO:0007744|PDB:4MSG, ECO:0007744|PDB:4MSK, ECO:0007744|PDB:4MT9, ECO:0007744|PDB:4N3R, ECO:0007744|PDB:4N4V, ECO:0007744|PDB:4OA7, ECO:0007744|PDB:4TOR, ECO:0007744|PDB:4TOS, ECO:0007744|PDB:4W5S, ECO:0007744|PDB:4W6E
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
14)
|
chain |
A |
| residue |
1237 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:18436240, ECO:0007744|PDB:2RF5, ECO:0007744|PDB:3UDD, ECO:0007744|PDB:3UH2, ECO:0007744|PDB:3UH4, ECO:0007744|PDB:4DVI, ECO:0007744|PDB:4I9I, ECO:0007744|PDB:4K4E, ECO:0007744|PDB:4K4F, ECO:0007744|PDB:4KRS, ECO:0007744|PDB:4LI6, ECO:0007744|PDB:4LI8, ECO:0007744|PDB:4MSG, ECO:0007744|PDB:4MSK, ECO:0007744|PDB:4MT9, ECO:0007744|PDB:4N3R, ECO:0007744|PDB:4N4V, ECO:0007744|PDB:4OA7, ECO:0007744|PDB:4TOR, ECO:0007744|PDB:4TOS, ECO:0007744|PDB:4W5S, ECO:0007744|PDB:4W6E
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
15)
|
chain |
A |
| residue |
1242 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:18436240, ECO:0007744|PDB:2RF5, ECO:0007744|PDB:3UDD, ECO:0007744|PDB:3UH2, ECO:0007744|PDB:3UH4, ECO:0007744|PDB:4DVI, ECO:0007744|PDB:4I9I, ECO:0007744|PDB:4K4E, ECO:0007744|PDB:4K4F, ECO:0007744|PDB:4KRS, ECO:0007744|PDB:4LI6, ECO:0007744|PDB:4LI8, ECO:0007744|PDB:4MSG, ECO:0007744|PDB:4MSK, ECO:0007744|PDB:4MT9, ECO:0007744|PDB:4N3R, ECO:0007744|PDB:4N4V, ECO:0007744|PDB:4OA7, ECO:0007744|PDB:4TOR, ECO:0007744|PDB:4TOS, ECO:0007744|PDB:4W5S, ECO:0007744|PDB:4W6E
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
16)
|
chain |
A |
| residue |
1245 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:18436240, ECO:0007744|PDB:2RF5, ECO:0007744|PDB:3UDD, ECO:0007744|PDB:3UH2, ECO:0007744|PDB:3UH4, ECO:0007744|PDB:4DVI, ECO:0007744|PDB:4I9I, ECO:0007744|PDB:4K4E, ECO:0007744|PDB:4K4F, ECO:0007744|PDB:4KRS, ECO:0007744|PDB:4LI6, ECO:0007744|PDB:4LI8, ECO:0007744|PDB:4MSG, ECO:0007744|PDB:4MSK, ECO:0007744|PDB:4MT9, ECO:0007744|PDB:4N3R, ECO:0007744|PDB:4N4V, ECO:0007744|PDB:4OA7, ECO:0007744|PDB:4TOR, ECO:0007744|PDB:4TOS, ECO:0007744|PDB:4W5S, ECO:0007744|PDB:4W6E
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|