|
|
eF-site ID
|
2r9r-A |
|
PDB Code
|
2r9r |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit |
|
Classification
|
MEMBRANE PROTEIN, TRANSPORT PROTEIN |
|
Compound
|
Voltage-gated potassium channel subunit beta-2 |
|
Source
|
Rattus norvegicus (Rat) (2R9R) |
|
|
Sequence
|
A: |
LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTL
AYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVI
TTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV
FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEI
MEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHK
IGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD
KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNE
GVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSIL
GNKPYS
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
262 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
2)
|
chain |
A |
| residue |
323 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000269|PubMed:23705070, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
3)
|
chain |
A |
| residue |
332 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
4)
|
chain |
A |
| residue |
112 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000269|PubMed:21357749
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
5)
|
chain |
A |
| residue |
124 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000250|UniProtKB:Q13303
|
| source |
Swiss-Prot : SWS_FT_FI12
|
|
|
6)
|
chain |
A |
| residue |
254 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
A |
| residue |
264 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
325 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
329 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
A |
| residue |
333 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
11)
|
chain |
A |
| residue |
57 |
| type |
BINDING |
| sequence |
W
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
12)
|
chain |
A |
| residue |
85 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
13)
|
chain |
A |
| residue |
188 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
14)
|
chain |
A |
| residue |
214 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
15)
|
chain |
A |
| residue |
243 |
| type |
BINDING |
| sequence |
W
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
16)
|
chain |
A |
| residue |
244 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
17)
|
chain |
A |
| residue |
246 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
18)
|
chain |
A |
| residue |
56 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
19)
|
chain |
A |
| residue |
63 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
20)
|
chain |
A |
| residue |
158 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:4JTA
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
21)
|
chain |
A |
| residue |
245 |
| type |
BINDING |
| sequence |
P
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
22)
|
chain |
A |
| residue |
247 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:4JTA
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
23)
|
chain |
A |
| residue |
248 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
24)
|
chain |
A |
| residue |
90 |
| type |
ACT_SITE |
| sequence |
Y
|
| description |
Proton donor/acceptor => ECO:0000305|PubMed:18672894
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
25)
|
chain |
A |
| residue |
189 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|