|
eF-site ID
|
2r92-ABCDEFGHIJKL |
PDB Code
|
2r92 |
Chain
|
A, B, C, D, E, F, G, H, I, J, K, L |
|
|
|
Title
|
Elongation complex of RNA polymerase II with artificial RdRP scaffold |
Classification
|
Transferase/RNA |
Compound
|
RNA (5'-R(*UP*GP*CP*AP*UP*AP*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3') |
Source
|
ORGANISM_COMMON: baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
Sequence
|
A: |
VGQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETM
DETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHF
GHIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNEL
MRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQL
VSRGGCGNTQPTIRKDGLKLVGSWKKDRDEPELRVLSTEE
ILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLPVPPPPV
RPSISFNESQRGEDDLTFKLADILKANISLETLEHNGAPH
HAIEEAESLLQFHVATYMDNDIAGQPQALQKSGRPVKSIR
ARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLELDQVGV
PKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVI
RDSGDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNR
QPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNADFDGDE
MNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMGIVQD
TLCGIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPTPAII
KPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKDNGML
IIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLF
GNIQKVVNFWLLHNGFSTGIGDTIADGPTMREITETIAEA
KKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVRFLNEAR
DKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVG
QQSVEGKRIAFGFVDRTLPHFSKDDYSPESKGFVENSYLR
GLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALE
DIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQSLDTI
GGSDAAFEKRYRVDLLNTDHTLDPSLLESGSEILGDLKLQ
VLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNIRRIIQN
AQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEI
IQNAQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVL
SNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMTLKKVTS
GVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQAKLIRS
AIEHTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQLHFSL
LQQSPWLLRLELDRAAMNDKDLTMGQVGERIKQTFKNDLF
VIWSEDNDEKLIIRCRVVRPAEEDHMLKKIENTMLENITL
RGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDGVNL
SEVMTVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVY
NVIASDGSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSN
TGALMRCSFEETVEILFEAGASAELDDCRGVSENVILGQM
APIGTGAFDVMIDEESLVKYMP
|
B: |
EDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYT
LQDIICEDSTLIISFGKIYVTKPMVNESDGVTHALYPQEA
RLRNLTYSSGLFVDVKKVFIGRLPIMLRSKNCYLSEATES
DLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFK
KAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSAR
TIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVND
WQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEK
RIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLL
CALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKD
IFRYMQRTVELAINAKTITSGLKYALATGNWGEQKKAMSS
RAGVSQVLNRYTYSSTLSHLRRTNTPIKPRQLHNTHWGLV
CPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWG
MEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRT
LRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVED
DESLGHKELKVRKGHIAKLMATEYQDEYTWSSLLNEGLVE
YIDAEEEESILIAMQPEDLEPAEADVDPAKRIRVSHHATT
FTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQA
MGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFREL
PAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFR
SYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDG
LIAPGVRVSGEDVIIGKTTPSKRDASTPLRSTENGIVDQV
LVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGI
TYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLS
KVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVM
YNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQ
VLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLM
EASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIY
QIHIPYAAKLLFQELMAMNITPRLYTDRSRDF
|
C: |
SEEGPQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEI
PTLAIDSVEVETNTTVLADEFIAHRLGLIPLQSMDIEQLE
YSRDCFCEDHCDKCSVVLTLQAFGESESTTNVYSKDLVIV
SNLMGRNIGHPIIQDKEGNGVLICKLRKGQELKLTCVAKK
GIAKEHAKWGPAAAIEFEYDPWNKLKHTDYWYEQDSAKEW
PQSKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPVD
QVVVRGIDTLQKKVASILLALTQMDQD
|
D: |
VSTSTFQTRRRRLKKVEEEENAATLQLGQEFQLKQINHQG
EEEELIALNLSEARLVIKEALVERRRAFKRSQKKTREKEL
ESIDVLLEQTTGGNNKDLKNTMQYLTNFSRFRDQETVGAV
IQLLKSTGLHPFEVAQLGSLACDTADEAKTLIPSLNNKIS
DDELERILKELSNLETLY
|
E: |
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLED
FKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVE
FCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAM
KLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEK
RELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRK
SETSGRYASYRICM
|
F: |
TLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPV
FVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWS
VEELIVDL
|
G: |
MFFIKDLSLNITLHPSFFGPRMKQYLKTKLLEEVEGSCTG
KFGYILCVLDYDNIDIQRGRILPTDGSAEFNVKYRAVVFK
PFKGEVVDGTVVSCSQHGFEVQVGPMKVFVTKHLMPQDLT
FNAGSNPPSYQSSEDVITIKSRIRVKIEGCISQVSSIHAI
GSIKEDYLGAI
|
H: |
SNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLD
INVELFPVAAQDSLTVTIASSLNLTRSWRPPQAGDRSLAD
DYDYVMYGTAYKFEEVSKDLIAVYYSFGGLLMRLEGNYRN
LNNLKQENAYLLIRR
|
I: |
TTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSP
LVYRHELITNIGETAGVVQDIGSDPTLPRSDRECPKCHSR
ENVFFQSQQRRKDTSMVLFFVCLSCSHIFTSDQKNK
|
J: |
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLG
LKRYCCRRMILTHVDLIEKFLRYNP
|
K: |
MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDH
TLGNLIRAELLNDRKVLFAAYKVEHPFFARFKLRIQTTEG
YDPKDALKNACNSIINKLGALKTNFETEWNLQ
|
L: |
ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRL
VQFEAR
|
|
Description
|
(1) |
PROTEIN/RNA Complex
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
837 |
type |
catalytic |
sequence |
D
|
description |
788
|
source |
MCSA : MCSA1
|
|
2)
|
chain |
A |
residue |
483 |
type |
catalytic |
sequence |
D
|
description |
788
|
source |
MCSA : MCSA1
|
|
3)
|
chain |
A |
residue |
485 |
type |
catalytic |
sequence |
D
|
description |
788
|
source |
MCSA : MCSA1
|
|
4)
|
chain |
I |
residue |
7 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
5)
|
chain |
I |
residue |
10 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
6)
|
chain |
I |
residue |
29 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
7)
|
chain |
I |
residue |
32 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
8)
|
chain |
I |
residue |
75 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00472, ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
9)
|
chain |
I |
residue |
78 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00472, ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
10)
|
chain |
I |
residue |
103 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00472, ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
11)
|
chain |
I |
residue |
106 |
type |
BINDING |
sequence |
C
|
description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00472, ECO:0000269|PubMed:11313498, ECO:0000269|PubMed:11805306, ECO:0000269|PubMed:15537538, ECO:0000305|PubMed:11313499
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
12)
|
chain |
I |
residue |
40 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine => ECO:0007744|PubMed:18407956
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
13)
|
chain |
J |
residue |
2-11 |
type |
prosite |
sequence |
IVPVRCFSCG
|
description |
RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFSCG
|
source |
prosite : PS01112
|
|
14)
|
chain |
F |
residue |
86-100 |
type |
prosite |
sequence |
TKYERARILGTRALQ
|
description |
RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ
|
source |
prosite : PS01111
|
|
15)
|
chain |
I |
residue |
75-110 |
type |
prosite |
sequence |
CPKCHSRENVFFQSQQRRKDTSMVLFFVCLSCSHIF
|
description |
ZF_TFIIS_1 Zinc finger TFIIS-type signature. CpkChsrenvffqSQQRRkDTSmvlffvCls...CshiF
|
source |
prosite : PS00466
|
|
16)
|
chain |
I |
residue |
6-32 |
type |
prosite |
sequence |
FCRDCNNMLYPREDKENNRLLFECRTC
|
description |
RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCrDCNNMLypredkennrllfeCrtC
|
source |
prosite : PS01030
|
|
17)
|
chain |
C |
residue |
31-71 |
type |
prosite |
sequence |
NSLRRVMIAEIPTLAIDSVEVETNTTVLADEFIAHRLGLI
P
|
description |
RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSLRRvmiaeiptlAidsVevetNtTvlaDEfIAhRLGLIP
|
source |
prosite : PS00446
|
|
18)
|
chain |
E |
residue |
147-160 |
type |
prosite |
sequence |
HELVPKHIRLSSDE
|
description |
RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLssDE
|
source |
prosite : PS01110
|
|
19)
|
chain |
K |
residue |
35-66 |
type |
prosite |
sequence |
FEKEDHTLGNLIRAELLNDRKVLFAAYKVEHP
|
description |
RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. FekEdHTLgNlIraeLlndrkVlfaaYkveHP
|
source |
prosite : PS01154
|
|
20)
|
chain |
B |
residue |
977-989 |
type |
prosite |
sequence |
GDKFASRHGQKGT
|
description |
RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT
|
source |
prosite : PS01166
|
|
21)
|
chain |
L |
residue |
31-51 |
type |
ZN_FING |
sequence |
CAECSSKLSLSRTDAVRCKDC
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
22)
|
chain |
A |
residue |
483 |
type |
ZN_FING |
sequence |
D
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
23)
|
chain |
A |
residue |
485 |
type |
ZN_FING |
sequence |
D
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
24)
|
chain |
J |
residue |
10 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
25)
|
chain |
J |
residue |
45 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
26)
|
chain |
J |
residue |
46 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
27)
|
chain |
A |
residue |
107 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
28)
|
chain |
A |
residue |
110 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
29)
|
chain |
A |
residue |
148 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
30)
|
chain |
A |
residue |
167 |
type |
ZN_FING |
sequence |
C
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
31)
|
chain |
A |
residue |
481 |
type |
ZN_FING |
sequence |
D
|
description |
C4-type
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
32)
|
chain |
L |
residue |
31 |
type |
BINDING |
sequence |
C
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
33)
|
chain |
L |
residue |
34 |
type |
BINDING |
sequence |
C
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
34)
|
chain |
L |
residue |
48 |
type |
BINDING |
sequence |
C
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
35)
|
chain |
L |
residue |
51 |
type |
BINDING |
sequence |
C
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
36)
|
chain |
B |
residue |
1185 |
type |
BINDING |
sequence |
C
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|