eF-site ID 2r4r-AHL PDB Code 2r4r Chain A, H, L click to enlarge Title Crystal structure of the human beta2 adrenoceptor Classification SIGNALING PROTEIN Compound Beta-2 adrenergic receptor Source ORGANISM_COMMON: house mouse; ORGANISM_SCIENTIFIC: Mus musculus; Sequence A:  GIVMSLIVLAIVFGNVLVITAIAFERLQTVTNYFITSLAC ADLVMGLAVVPFGFWTSIDVLCVTASIETLCVIAVDRYFA ITSPFKYQSLLTKNKARVIILMVWIVSGLTSSIVSFYVPL VIMVFVYSRVFQEAKRQLQKIDKSEGRFHVFCLKEHKALK TLGIIMGTFTLCWLPFFILNWIGYVNSGFNPLIYCRSPDF RIAFQELLCLRRSSLK H:  EVQLQQSGAELARPGASVKLSCKASGYIFTDYYINWVRQR TGQGFEWIGEIYPGSGNIDYNERFKDKATLTADKSSSTAY MQLSSLTSEDSAVYFCVRGFGYWGQGTTLTVSSAKTTPPS VYPLAPGSAAQTNSAVTLGCLVKGYFPEPVTVTWNSGSLS SGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHP ASSTKVDKKIVPRDCGC L:  DIKMTQSPSSMYASLGERVTITCKASQDINSYLSWFQQKP GKSPKTLIYRANRLVDGVPSRFIGTGSGQDYSLTISSLDY ADMGIYYCLQYDEFPYTFGGGTKLEIKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKT STSPIVKSFNRNEC Description Functional site 1) chain A residue 119-135 type prosite sequence ASIETLCVIAVDRYFAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAVDRYFaI source prosite : PS00237 2) chain A residue 59-71 type TOPO_DOM sequence AFERLQTVTNYF description Cytoplasmic source Swiss-Prot : SWS_FT_FI3 3) chain A residue 130-150 type TOPO_DOM sequence DRYFAITSPFKYQSLLTKNKA description Cytoplasmic source Swiss-Prot : SWS_FT_FI3 4) chain A residue 221-274 type TOPO_DOM sequence RVFQEAKRQLQKIDKSEGRFHVFCLKEHKALKT description Cytoplasmic source Swiss-Prot : SWS_FT_FI3 5) chain A residue 113 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 6) chain A residue 118 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 7) chain A residue 312 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 8) chain A residue 316 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 9) chain A residue 203 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17952055, ECO:0000269|PubMed:17962520, ECO:0007744|PDB:2RH1 source Swiss-Prot : SWS_FT_FI11 10) chain A residue 141 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8521811 source Swiss-Prot : SWS_FT_FI12 11) chain A residue 345 type MOD_RES sequence S description Phosphoserine; by PKA => ECO:0000269|PubMed:11146000 source Swiss-Prot : SWS_FT_FI15 12) chain A residue 346 type MOD_RES sequence S description Phosphoserine; by PKA => ECO:0000269|PubMed:11146000 source Swiss-Prot : SWS_FT_FI15 13) chain A residue 265 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI17 14) chain A residue 341 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:17962520, ECO:0000269|PubMed:18547522, ECO:0000269|PubMed:2540197, ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI18 15) chain L residue 192-198 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290

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