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eF-site ID
|
2r0k-AHL |
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PDB Code
|
2r0k |
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Chain
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A, H, L |
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click to enlarge
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Title
|
Protease domain of HGFA with inhibitor Fab58 |
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Classification
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HYDROLASE, IMMUNE SYSTEM |
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Compound
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Hepatocyte growth factor activator |
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Source
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Homo sapiens (Human) (2R0K) |
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Sequence
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A: |
IIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAH
CFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTL
YSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGS
TFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKC
SSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKN
GVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIR
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| H: |
EVQLVESGGGLVQPGGSLRLSCAASGFTITGSAIHWVRQA
PGKGLEWVAIINPNGGYTYYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAVYYCARSARFSFDYWGQGTLVTVSSAST
KGPSVFPLAPGTAALGCLVKDYFPEPVTVSWNSGALTSGV
HTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPS
NTKVDKKVEPKSC
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| L: |
DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKP
GKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQSYTTPPTFGQGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGEC
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Description
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Functional site
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|
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1)
|
chain |
A |
| residue |
53-58 |
| type |
prosite |
| sequence |
VSAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
|
| source |
prosite : PS00134
|
|
|
2)
|
chain |
A |
| residue |
189-200 |
| type |
prosite |
| sequence |
DACQGDSGGPLA
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPLA
|
| source |
prosite : PS00135
|
|
|
3)
|
chain |
L |
| residue |
192-198 |
| type |
prosite |
| sequence |
YACEVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
|
|
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4)
|
chain |
H |
| residue |
194-200 |
| type |
prosite |
| sequence |
YICNVNH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
|
|
|
5)
|
chain |
A |
| residue |
57 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system => ECO:0000269|PubMed:15713485
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
A |
| residue |
102 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system => ECO:0000269|PubMed:15713485
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
195 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Charge relay system => ECO:0000269|PubMed:15713485
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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8)
|
chain |
A |
| residue |
74 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:18077410, ECO:0000269|PubMed:19159218
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
147 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|