eF-site ID 2qfs-A
PDB Code 2qfs
Chain A

click to enlarge
Title E.coli EPSP synthase Pro101Ser liganded with S3P
Classification TRANSFERASE
Compound 3-phosphoshikimate 1-carboxyvinyltransferase
Source null (AROA_ECOLI)
Sequence A:  MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTV
LTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGG
PLHAEGALELFLGNAGTAMRSLAAALCLGSNDIVLTGEPR
MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGG
NVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPY
IDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE
GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVL
EKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIAT
AALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE
EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTP
VTILDPKCTAKTFPDYFEQLARISQAA
Description


Functional site
1) chain A
residue 22
type
sequence K
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
2) chain A
residue 23
type
sequence S
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
3) chain A
residue 27
type
sequence R
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
4) chain A
residue 97
type
sequence T
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
5) chain A
residue 169
type
sequence S
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
6) chain A
residue 170
type
sequence S
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
7) chain A
residue 171
type
sequence Q
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
8) chain A
residue 197
type
sequence S
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
9) chain A
residue 200
type
sequence Y
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
10) chain A
residue 313
type
sequence D
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
11) chain A
residue 336
type
sequence N
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
12) chain A
residue 340
type
sequence K
description BINDING SITE FOR RESIDUE S3P A 701
source : AC1
13) chain A
residue 22
type
sequence K
description BINDING SITE FOR RESIDUE FMT A 601
source : AC2
14) chain A
residue 313
type
sequence D
description BINDING SITE FOR RESIDUE FMT A 601
source : AC2
15) chain A
residue 341
type
sequence E
description BINDING SITE FOR RESIDUE FMT A 601
source : AC2
16) chain A
residue 344
type
sequence R
description BINDING SITE FOR RESIDUE FMT A 601
source : AC2
17) chain A
residue 385
type
sequence H
description BINDING SITE FOR RESIDUE FMT A 601
source : AC2
18) chain A
residue 386
type
sequence R
description BINDING SITE FOR RESIDUE FMT A 601
source : AC2
19) chain A
residue 22
type
sequence K
description BINDING SITE FOR RESIDUE FMT A 602
source : AC3
20) chain A
residue 94
type
sequence N
description BINDING SITE FOR RESIDUE FMT A 602
source : AC3
21) chain A
residue 96
type
sequence G
description BINDING SITE FOR RESIDUE FMT A 602
source : AC3
22) chain A
residue 97
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 602
source : AC3
23) chain A
residue 124
type
sequence R
description BINDING SITE FOR RESIDUE FMT A 602
source : AC3
24) chain A
residue 171
type
sequence Q
description BINDING SITE FOR RESIDUE FMT A 602
source : AC3
25) chain A
residue 341
type
sequence E
description BINDING SITE FOR RESIDUE FMT A 602
source : AC3
26) chain A
residue 411
type
sequence K
description BINDING SITE FOR RESIDUE FMT A 602
source : AC3
27) chain A
residue 380
type
sequence A
description BINDING SITE FOR RESIDUE FMT A 603
source : AC4
28) chain A
residue 382
type
sequence Y
description BINDING SITE FOR RESIDUE FMT A 603
source : AC4
29) chain A
residue 373
type
sequence K
description BINDING SITE FOR RESIDUE FMT A 604
source : AC5
30) chain A
residue 374
type
sequence L
description BINDING SITE FOR RESIDUE FMT A 604
source : AC5
31) chain A
residue 397
type
sequence S
description BINDING SITE FOR RESIDUE FMT A 604
source : AC5
32) chain A
residue 398
type
sequence D
description BINDING SITE FOR RESIDUE FMT A 604
source : AC5
33) chain A
residue 58
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 605
source : AC6
34) chain A
residue 62
type
sequence V
description BINDING SITE FOR RESIDUE FMT A 605
source : AC6
35) chain A
residue 63
type
sequence S
description BINDING SITE FOR RESIDUE FMT A 605
source : AC6
36) chain A
residue 64
type
sequence Y
description BINDING SITE FOR RESIDUE FMT A 605
source : AC6
37) chain A
residue 5
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 606
source : AC7
38) chain A
residue 141
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 606
source : AC7
39) chain A
residue 143
type
sequence L
description BINDING SITE FOR RESIDUE FMT A 606
source : AC7
40) chain A
residue 152
type
sequence R
description BINDING SITE FOR RESIDUE FMT A 606
source : AC7
41) chain A
residue 376
type
sequence F
description BINDING SITE FOR RESIDUE FMT A 606
source : AC7
42) chain A
residue 402
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 606
source : AC7
43) chain A
residue 65
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 607
source : AC8
44) chain A
residue 66
type
sequence L
description BINDING SITE FOR RESIDUE FMT A 607
source : AC8
45) chain A
residue 67
type
sequence S
description BINDING SITE FOR RESIDUE FMT A 607
source : AC8
46) chain A
residue 72
type
sequence R
description BINDING SITE FOR RESIDUE FMT A 607
source : AC8
47) chain A
residue 74
type
sequence E
description BINDING SITE FOR RESIDUE FMT A 607
source : AC8
48) chain A
residue 11
type
sequence R
description BINDING SITE FOR RESIDUE FMT A 608
source : AC9
49) chain A
residue 13
type
sequence D
description BINDING SITE FOR RESIDUE FMT A 608
source : AC9
50) chain A
residue 220
type
sequence Y
description BINDING SITE FOR RESIDUE FMT A 608
source : AC9
51) chain A
residue 425
type
sequence Q
description BINDING SITE FOR RESIDUE FMT A 608
source : AC9
52) chain A
residue 38
type
sequence K
description BINDING SITE FOR RESIDUE FMT A 609
source : BC1
53) chain A
residue 335
type
sequence Y
description BINDING SITE FOR RESIDUE FMT A 609
source : BC1
54) chain A
residue 363
type
sequence H
description BINDING SITE FOR RESIDUE FMT A 609
source : BC1
55) chain A
residue 298
type
sequence R
description BINDING SITE FOR RESIDUE FMT A 610
source : BC2
56) chain A
residue 300
type
sequence E
description BINDING SITE FOR RESIDUE FMT A 610
source : BC2
57) chain A
residue 301
type
sequence L
description BINDING SITE FOR RESIDUE FMT A 610
source : BC2
58) chain A
residue 324
type
sequence F
description BINDING SITE FOR RESIDUE FMT A 610
source : BC2
59) chain A
residue 13
type
sequence D
description BINDING SITE FOR RESIDUE FMT A 611
source : BC3
60) chain A
residue 14
type
sequence G
description BINDING SITE FOR RESIDUE FMT A 611
source : BC3
61) chain A
residue 259
type
sequence T
description BINDING SITE FOR RESIDUE FMT A 611
source : BC3
62) chain A
residue 36
type
sequence H
description BINDING SITE FOR RESIDUE FMT A 612
source : BC4
63) chain A
residue 79
type
sequence G
description BINDING SITE FOR RESIDUE FMT A 612
source : BC4
64) chain A
residue 80
type
sequence G
description BINDING SITE FOR RESIDUE FMT A 612
source : BC4
65) chain A
residue 182
type
sequence L
description BINDING SITE FOR RESIDUE FMT A 612
source : BC4
66) chain A
residue 230
type
sequence S
description BINDING SITE FOR RESIDUE FMT A 612
source : BC4
67) chain A
residue 408
type SITE
sequence C
description Modified by bromopyruvate => ECO:0000269|PubMed:11171958
source Swiss-Prot : SWS_FT_FI6
68) chain A
residue 411
type SITE
sequence K
description Modified by bromopyruvate => ECO:0000269|PubMed:11171958
source Swiss-Prot : SWS_FT_FI6
69) chain A
residue 313
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI1
70) chain A
residue 341
type ACT_SITE
sequence E
description Proton donor => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:15736934, ECO:0000305|PubMed:11171958
source Swiss-Prot : SWS_FT_FI2
71) chain A
residue 22
type BINDING
sequence K
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI3
72) chain A
residue 169
type BINDING
sequence S
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI3
73) chain A
residue 340
type BINDING
sequence K
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI3
74) chain A
residue 27
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI4
75) chain A
residue 197
type BINDING
sequence S
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI4
76) chain A
residue 336
type BINDING
sequence N
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:15736934, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:17958399, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI4
77) chain A
residue 124
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI5
78) chain A
residue 344
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI5
79) chain A
residue 386
type BINDING
sequence R
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI5
80) chain A
residue 411
type BINDING
sequence K
description BINDING => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:11171958, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556
source Swiss-Prot : SWS_FT_FI5
81) chain A
residue 90-104
type prosite
sequence LFLGNAGTAMRSLAA
description EPSP_SYNTHASE_1 EPSP synthase signature 1. LFlGNAGTAMRsLaA
source prosite : PS00104
82) chain A
residue 338-356
type prosite
sequence RVKETDRLFAMATELRKVG
description EPSP_SYNTHASE_2 EPSP synthase signature 2. RvKETDRLfAMateLrkVG
source prosite : PS00885
83) chain A
residue 49
type catalytic
sequence D
description 457
source MCSA : MCSA1
84) chain A
residue 94
type catalytic
sequence N
description 457
source MCSA : MCSA1
85) chain A
residue 313
type catalytic
sequence D
description 457
source MCSA : MCSA1
86) chain A
residue 341
type catalytic
sequence E
description 457
source MCSA : MCSA1
87) chain A
residue 385
type catalytic
sequence H
description 457
source MCSA : MCSA1
88) chain A
residue 386
type catalytic
sequence R
description 457
source MCSA : MCSA1
89) chain A
residue 411
type catalytic
sequence K
description 457
source MCSA : MCSA1

Display surface

Download
Links