eF-site ID 2qfa-A
PDB Code 2qfa
Chain A

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Title Crystal structure of a Survivin-Borealin-INCENP core complex
Classification Cell cycle/Cell cycle/Cell cycle
Compound Baculoviral IAP repeat-containing protein 5
Source Homo sapiens (Human) (INCE_HUMAN)
Sequence A:  TLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFI
HCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGC
AFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEF
EETAKKVRRAIEQLAAM
Description


Functional site

1) chain A
residue 57
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 143
source : AC1

2) chain A
residue 60
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 143
source : AC1

3) chain A
residue 77
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 143
source : AC1

4) chain A
residue 84
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 143
source : AC1

5) chain A
residue 18
type
sequence R
description BINDING SITE FOR RESIDUE MES A 975
source : AC2

6) chain A
residue 40
type
sequence E
description BINDING SITE FOR RESIDUE MES A 975
source : AC2

7) chain A
residue 86
type
sequence F
description BINDING SITE FOR RESIDUE MES A 975
source : AC2

8) chain A
residue 89
type
sequence V
description BINDING SITE FOR RESIDUE MES A 975
source : AC2

9) chain A
residue 92
type
sequence Q
description BINDING SITE FOR RESIDUE MES A 975
source : AC2

10) chain A
residue 93
type
sequence F
description BINDING SITE FOR RESIDUE MES A 975
source : AC2

11) chain A
residue 57
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:17956729, ECO:0007744|PDB:2QFA
source Swiss-Prot : SWS_FT_FI1

12) chain A
residue 60
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:17956729, ECO:0007744|PDB:2QFA
source Swiss-Prot : SWS_FT_FI1

13) chain A
residue 77
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:17956729, ECO:0007744|PDB:2QFA
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 84
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:17956729, ECO:0007744|PDB:2QFA
source Swiss-Prot : SWS_FT_FI1

15) chain A
residue 126
type SITE
sequence E
description Interaction with FBXL7 => ECO:0000269|PubMed:25778398
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 20
type MOD_RES
sequence S
description Phosphoserine; by AURKC => ECO:0000269|PubMed:27332895
source Swiss-Prot : SWS_FT_FI3

17) chain A
residue 23
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:20826784
source Swiss-Prot : SWS_FT_FI4

18) chain A
residue 90
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:20826784
source Swiss-Prot : SWS_FT_FI4

19) chain A
residue 110
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:20826784
source Swiss-Prot : SWS_FT_FI4

20) chain A
residue 112
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:20826784
source Swiss-Prot : SWS_FT_FI4

21) chain A
residue 115
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:20826784
source Swiss-Prot : SWS_FT_FI4

22) chain A
residue 121
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:20826784
source Swiss-Prot : SWS_FT_FI4

23) chain A
residue 129
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000269|PubMed:20826784
source Swiss-Prot : SWS_FT_FI4

24) chain A
residue 34
type MOD_RES
sequence T
description Phosphothreonine; by CDK1 and CDK15 => ECO:0000269|PubMed:11069302, ECO:0000269|PubMed:24866247, ECO:0007744|PubMed:18691976
source Swiss-Prot : SWS_FT_FI5

25) chain A
residue 48
type MOD_RES
sequence T
description Phosphothreonine; by CK2; in vitro => ECO:0000269|PubMed:21252625
source Swiss-Prot : SWS_FT_FI6

26) chain A
residue 117
type MOD_RES
sequence T
description Phosphothreonine; by AURKB => ECO:0000269|PubMed:14610074
source Swiss-Prot : SWS_FT_FI7


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