Title
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Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor |
Classification
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TRANSFERASE |
Compound
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RNA-directed RNA polymerase |
Source
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Hepatitis C virus subtype 1b (Q99AU2_9HEPC) |
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Sequence
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A: |
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT
TSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA
KLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH
SVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLI
VFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQR
VEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCR
ASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDL
VVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETA
RHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLE
KALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAAT
CGKYLFNWAVKTKLKLTPIPAASLSGWFVAGYSGGDIYH
|
C: |
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT
TSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA
KLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH
SVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLI
VFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQR
VEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCR
ASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDL
VVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETA
RHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLE
KALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAAT
CGKYLFNWAVKTKLKLTPIPAASLSGWFVAGYSGGDIYH
|
D: |
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT
TSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA
KLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIH
SVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLI
VFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQR
VEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCR
ASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDL
VVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETA
RHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLE
KALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAAT
CGKYLFNWAVKTKLKLTPIPAASLSGWFVAGYSGGDIYH
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Description
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