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Title
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Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor |
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Classification
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TRANSFERASE |
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Compound
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RNA-directed RNA polymerase |
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Source
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Hepatitis C virus subtype 1b (Q99AU2_9HEPC) |
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Sequence
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A: |
LLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLK
EMKAKASTVKAKLLSVEEACKLTPPHSAFGYGAKDVRNLS
SKAVNHIHSVWKDLLEDPIDTTIMAKNEVFCVQPEGGRKP
ARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYS
PGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVE
ESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGY
RRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVN
GDDLVVICESAGTQEDAASLRVFTEAMTRYPPGDPPQPEY
DLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWE
TARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQ
LEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYS
PGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRA
ATCGKYLFNWAVKTKLKLTPIPAASLSGWFVAGYSGGDIY
H
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| B: |
RHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEM
KAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNL
SSKAVNHIHSVWKDLLEDPIDTTIMAKNEVFCVQPEKGGR
KPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQ
YSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIR
VEESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNC
GYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTML
VNGDDLVVICESAGTQEDAASLRVFTEAMTRYPPGDPPQP
EYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAA
WETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQ
EQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHS
YSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGG
RAATCGKYLFNWAVKTKLKLTPIPAASLSGWFVAGYSGGD
IYH
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Description
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