eF-site ID 2qc8-J PDB Code 2qc8 Chain J click to enlarge Title Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate Classification LIGASE Compound Glutamine synthetase Source Homo sapiens (Human) (GLNA_HUMAN) Sequence J:  NKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDS EPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPF RKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHP WFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADR AYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPC EGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNG AGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYD PKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTV GQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETG Description Functional site 1) chain J residue 136 type sequence E description BINDING SITE FOR RESIDUE MN J 401 source : DC1 2) chain J residue 196 type sequence E description BINDING SITE FOR RESIDUE MN J 401 source : DC1 3) chain J residue 203 type sequence E description BINDING SITE FOR RESIDUE MN J 401 source : DC1 4) chain J residue 134 type sequence E description BINDING SITE FOR RESIDUE MN J 402 source : DC2 5) chain J residue 253 type sequence H description BINDING SITE FOR RESIDUE MN J 402 source : DC2 6) chain J residue 338 type sequence E description BINDING SITE FOR RESIDUE MN J 402 source : DC2 7) chain J residue 134 type sequence E description BINDING SITE FOR RESIDUE MN J 403 source : DC3 8) chain J residue 203 type sequence E description BINDING SITE FOR RESIDUE MN J 403 source : DC3 9) chain J residue 44 type sequence T description BINDING SITE FOR RESIDUE CL F 706 source : DC9 10) chain J residue 193 type sequence T description BINDING SITE FOR RESIDUE CL J 710 source : EC4 11) chain J residue 63 type sequence D description BINDING SITE FOR RESIDUE P3S F 601 source : FC7 12) chain J residue 130 type sequence W description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 13) chain J residue 132 type sequence G description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 14) chain J residue 134 type sequence E description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 15) chain J residue 191 type sequence A description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 16) chain J residue 203 type sequence E description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 17) chain J residue 205 type sequence Q description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 18) chain J residue 207 type sequence G description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 19) chain J residue 208 type sequence P description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 20) chain J residue 255 type sequence N description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 21) chain J residue 257 type sequence S description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 22) chain J residue 319 type sequence R description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 23) chain J residue 324 type sequence R description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 24) chain J residue 336 type sequence Y description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 25) chain J residue 338 type sequence E description BINDING SITE FOR RESIDUE ADP J 501 source : GC5 26) chain J residue 134 type sequence E description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 27) chain J residue 136 type sequence E description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 28) chain J residue 162 type sequence Y description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 29) chain J residue 196 type sequence E description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 30) chain J residue 203 type sequence E description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 31) chain J residue 249 type sequence G description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 32) chain J residue 253 type sequence H description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 33) chain J residue 299 type sequence R description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 34) chain J residue 305 type sequence E description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 35) chain J residue 306 type sequence T description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 36) chain J residue 319 type sequence R description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 37) chain J residue 338 type sequence E description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 38) chain J residue 340 type sequence R description BINDING SITE FOR RESIDUE P3S J 601 source : GC6 39) chain J residue 104 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P15105 source Swiss-Prot : SWS_FT_FI4 40) chain J residue 343 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5 41) chain J residue 134 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 42) chain J residue 136 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 43) chain J residue 196 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 44) chain J residue 203 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 45) chain J residue 253 type BINDING sequence H description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 46) chain J residue 338 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 47) chain J residue 246 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 48) chain J residue 319 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 49) chain J residue 340 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 50) chain J residue 255 type BINDING sequence N description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 51) chain J residue 324 type BINDING sequence R description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 52) chain J residue 336 type BINDING sequence Y description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3

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