eF-site ID 2qc8-B PDB Code 2qc8 Chain B click to enlarge Title Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate Classification LIGASE Compound Glutamine synthetase Source null (GLNA_HUMAN) Sequence B:  NKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDS EPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPF RKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHP WFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADR AYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPC EGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNG AGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYD PKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTV GQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETG Description Functional site 1) chain B residue 136 type sequence E description BINDING SITE FOR RESIDUE MN B 401 source : AC4 2) chain B residue 196 type sequence E description BINDING SITE FOR RESIDUE MN B 401 source : AC4 3) chain B residue 203 type sequence E description BINDING SITE FOR RESIDUE MN B 401 source : AC4 4) chain B residue 134 type sequence E description BINDING SITE FOR RESIDUE MN B 402 source : AC5 5) chain B residue 253 type sequence H description BINDING SITE FOR RESIDUE MN B 402 source : AC5 6) chain B residue 338 type sequence E description BINDING SITE FOR RESIDUE MN B 402 source : AC5 7) chain B residue 340 type sequence R description BINDING SITE FOR RESIDUE MN B 402 source : AC5 8) chain B residue 134 type sequence E description BINDING SITE FOR RESIDUE MN B 403 source : AC6 9) chain B residue 203 type sequence E description BINDING SITE FOR RESIDUE MN B 403 source : AC6 10) chain B residue 29 type sequence M description BINDING SITE FOR RESIDUE CL B 701 source : DC4 11) chain B residue 44 type sequence T description BINDING SITE FOR RESIDUE CL B 701 source : DC4 12) chain B residue 193 type sequence T description BINDING SITE FOR RESIDUE CL B 705 source : DC8 13) chain B residue 130 type sequence W description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 14) chain B residue 132 type sequence G description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 15) chain B residue 134 type sequence E description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 16) chain B residue 203 type sequence E description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 17) chain B residue 205 type sequence Q description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 18) chain B residue 206 type sequence I description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 19) chain B residue 207 type sequence G description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 20) chain B residue 208 type sequence P description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 21) chain B residue 255 type sequence N description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 22) chain B residue 257 type sequence S description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 23) chain B residue 319 type sequence R description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 24) chain B residue 324 type sequence R description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 25) chain B residue 336 type sequence Y description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 26) chain B residue 338 type sequence E description BINDING SITE FOR RESIDUE ADP B 501 source : EC7 27) chain B residue 134 type sequence E description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 28) chain B residue 136 type sequence E description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 29) chain B residue 162 type sequence Y description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 30) chain B residue 196 type sequence E description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 31) chain B residue 203 type sequence E description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 32) chain B residue 249 type sequence G description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 33) chain B residue 253 type sequence H description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 34) chain B residue 299 type sequence R description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 35) chain B residue 305 type sequence E description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 36) chain B residue 306 type sequence T description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 37) chain B residue 319 type sequence R description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 38) chain B residue 338 type sequence E description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 39) chain B residue 340 type sequence R description BINDING SITE FOR RESIDUE P3S B 601 source : EC8 40) chain B residue 63 type sequence D description BINDING SITE FOR RESIDUE P3S C 601 source : FC1 41) chain B residue 203 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 253 type BINDING sequence H description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 338 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 134 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 136 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 46) chain B residue 196 type BINDING sequence E description BINDING => ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI1 47) chain B residue 246 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 319 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 49) chain B residue 340 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WN39 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 255 type BINDING sequence N description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 51) chain B residue 324 type BINDING sequence R description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 52) chain B residue 336 type BINDING sequence Y description BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8 source Swiss-Prot : SWS_FT_FI3 53) chain B residue 104 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P15105 source Swiss-Prot : SWS_FT_FI4 54) chain B residue 343 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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