|
|
eF-site ID
|
2q6f-B |
|
PDB Code
|
2q6f |
|
Chain
|
B |
|
click to enlarge
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Title
|
Crystal structure of infectious bronchitis virus (IBV) main protease in complex with a Michael acceptor inhibitor N3 |
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Classification
|
HYDROLASE |
|
Compound
|
Infectious bronchitis virus (IBV) main protease |
|
Source
|
Infectious bronchitis virus (2Q6F) |
|
|
Sequence
|
B: |
SGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDSIYCPR
HVLGKFSGDQWGDVLNLANNHEFEVVTQNGVTLNVVSRRL
KGAVLILQTAVANAETPKYKFVKANCGDSFTIACSYGGTV
IGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYM
HHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTN
NIVAWLYAAIISVPKWLESTTVSIEDYNRWASDNGFTPFS
TSTAITKLSAITGVDVCKLLRTIMVKSAQWGSDPILGQYN
FEDELTPESVFNQVG
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|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
25 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
2)
|
chain |
B |
| residue |
26 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
3)
|
chain |
B |
| residue |
27 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
4)
|
chain |
B |
| residue |
41 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
5)
|
chain |
B |
| residue |
138 |
| type |
|
| sequence |
F
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
6)
|
chain |
B |
| residue |
141 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
7)
|
chain |
B |
| residue |
142 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
8)
|
chain |
B |
| residue |
143 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
9)
|
chain |
B |
| residue |
161 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
10)
|
chain |
B |
| residue |
162 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
11)
|
chain |
B |
| residue |
163 |
| type |
|
| sequence |
L
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
12)
|
chain |
B |
| residue |
164 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
13)
|
chain |
B |
| residue |
170 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
14)
|
chain |
B |
| residue |
187 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
15)
|
chain |
B |
| residue |
188 |
| type |
|
| sequence |
V
|
| description |
BINDING SITE FOR CHAIN C
|
| source |
: AC2
|
|
|
16)
|
chain |
B |
| residue |
41 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
17)
|
chain |
B |
| residue |
143 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|