eF-site ID 2q5s-B PDB Code 2q5s Chain B click to enlarge Title Crystal Structure of PPARgamma bound to partial agonist nTZDpa Classification Ligand binding protein Compound Peroxisome Proliferator-Activated Receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKKSPFVI YDMNSLMMGEDKIKFKHKEVAIRIFQGCQFRSVEAVQEIT EYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKD GVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNAL ELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK KTETDMLHPLLQEIYKDL Description Functional site 1) chain B residue 281 type sequence I description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 2) chain B residue 284 type sequence G description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 3) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 4) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 5) chain B residue 292 type sequence A description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 6) chain B residue 333 type sequence L description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 7) chain B residue 340 type sequence L description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 8) chain B residue 341 type sequence I description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 9) chain B residue 342 type sequence S description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 10) chain B residue 348 type sequence M description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 11) chain B residue 363 type sequence F description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 12) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 13) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 14) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 15) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 16) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 17) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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