eF-site ID 2q5s-AB PDB Code 2q5s Chain A, B click to enlarge Title Crystal Structure of PPARgamma bound to partial agonist nTZDpa Classification Ligand binding protein Compound Peroxisome Proliferator-Activated Receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPF VIYDMNSLMMGEDKEVAIRIFQGCQFRSVEAVQEITEYAK SIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLI SEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQL KLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTET DMSLHPLLQEIYKDLY B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKKSPFVI YDMNSLMMGEDKIKFKHKEVAIRIFQGCQFRSVEAVQEIT EYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKD GVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNAL ELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK KTETDMLHPLLQEIYKDL Description Functional site 1) chain B residue 281 type sequence I description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 2) chain B residue 284 type sequence G description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 3) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 4) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 5) chain B residue 292 type sequence A description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 6) chain B residue 333 type sequence L description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 7) chain B residue 340 type sequence L description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 8) chain B residue 341 type sequence I description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 9) chain B residue 342 type sequence S description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 10) chain B residue 348 type sequence M description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 11) chain B residue 363 type sequence F description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 12) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE NZA B 5001 source : AC1 13) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 14) chain A residue 284 type sequence G description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 15) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 16) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 17) chain A residue 292 type sequence A description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 18) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 19) chain A residue 333 type sequence L description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 20) chain A residue 340 type sequence L description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 21) chain A residue 341 type sequence I description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 22) chain A residue 342 type sequence S description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 23) chain A residue 348 type sequence M description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 24) chain A residue 353 type sequence L description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 25) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE NZA A 7001 source : AC2 26) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 27) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 28) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 29) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 30) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 31) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 32) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 33) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 34) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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